Structure of PDB 1beh Chain A Binding Site BS01

Receptor Information

>1beh Chain A (length=184) Species: 9606 (Homo sapiens)

VDLSKWSGPLSLQEVDEQPQHPLHVTYAGAAVDELGKVLTPTQVKNRPTS
ISWDGLDSGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNDISSGTV
LSDYVGSGPPKGTGLHRYVWLVYEQDRPLKCDEPILSNRSGDHRGKFKVA
SFRKKYELRAPVAGTCYQAEWDDYVPKLYEQLSG

Ligand information

• Ligand ID: CAC
• InChI: InChI=1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5)/p-1
• InChIKey: OGGXGZAMXPVRFZ-UHFFFAOYSA-M
• SMILES:
  OpenEye OEToolkits 1.7.0: C[As](=O)(C)[O-]
  CACTVS 3.370: C[As](C)([O-])=O
  ACDLabs 12.01: [O-][As](=O)(C)C
• Formula: C2 H6 As O2
• Name: CACODYLATE ION;
  dimethylarsinate
• PDB chain: 1beh Chain A Residue 188

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1beh Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction.
• Resolution: 1.75 Å
• Binding residue (original residue number in PDB): D70 W84 H86 G110 Y120
• Binding residue (residue number reindexed from 1): D68 W82 H84 G108 Y118
• Annotation score: 3

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004867 serine-type endopeptidase inhibitor activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0008289 lipid binding
• GO:0008429 phosphatidylethanolamine binding
• GO:0019899 enzyme binding
• GO:0019901 protein kinase binding

Biological Process

• GO:0010466 negative regulation of peptidase activity
• GO:0043409 negative regulation of MAPK cascade

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:1beh, PDBe:1beh, PDBj:1beh
• PDBsum: 1beh
• PubMed: 9782050
• UniProt: P30086|PEBP1_HUMAN Phosphatidylethanolamine-binding protein 1 (Gene Name=PEBP1)