Structure of PDB 1bb6 Chain A Binding Site BS01
Receptor Information
>1bb6 Chain A (length=129) Species:
8022
(Oncorhynchus mykiss) [
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KVYDRCELARALKASGMDGYAGNSLPNWVCLSKWESSYNTQATNRNTDGS
TDYGIFQINSRYWCDDGRTPGAKNVCGIRCSQLLTDDLTVAIRCAKRVVL
DPNGIGAWVAWRLHCQNQDLRSYVAGCGV
Ligand information
Ligand ID
UMG
InChI
InChI=1S/C34H47N3O18/c1-12-7-22(44)50-18-8-16(5-6-17(12)18)49-32-24(36-14(3)42)28(47)30(20(10-39)52-32)55-34-25(37-15(4)43)29(48)31(21(11-40)53-34)54-33-23(35-13(2)41)27(46)26(45)19(9-38)51-33/h5-8,19-21,23-34,38-40,45-48H,9-11H2,1-4H3,(H,35,41)(H,36,42)(H,37,43)/t19-,20-,21-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+/m1/s1
InChIKey
BNYGKUQXGBVTRE-ITRNKESMSA-N
SMILES
Software
SMILES
CACTVS 3.341
CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](NC(C)=O)[C@@H](O[C@@H]2CO)O[C@H]3[C@H](O)[C@@H](NC(C)=O)[C@H](O[C@@H]3CO)Oc4ccc5C(=CC(=O)Oc5c4)C
ACDLabs 10.04
O=C5Oc4c(ccc(OC3OC(C(OC2OC(C(OC1OC(CO)C(O)C(O)C1NC(=O)C)C(O)C2NC(=O)C)CO)C(O)C3NC(=O)C)CO)c4)C(=C5)C
OpenEye OEToolkits 1.5.0
CC1=CC(=O)Oc2c1ccc(c2)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)NC(=O)C)O)NC(=O)C)O)NC(=O)C
CACTVS 3.341
CC(=O)N[CH]1[CH](O)[CH](O)[CH](CO)O[CH]1O[CH]2[CH](O)[CH](NC(C)=O)[CH](O[CH]2CO)O[CH]3[CH](O)[CH](NC(C)=O)[CH](O[CH]3CO)Oc4ccc5C(=CC(=O)Oc5c4)C
OpenEye OEToolkits 1.5.0
CC1=CC(=O)Oc2c1ccc(c2)OC3C(C(C(C(O3)CO)OC4C(C(C(C(O4)CO)OC5C(C(C(C(O5)CO)O)O)NC(=O)C)O)NC(=O)C)O)NC(=O)C
Formula
C34 H47 N3 O18
Name
METHYL-UMBELLIFERTL-N-ACETYL-CHITOTRIOSE;
METHYLUMBELLIFERYL CHITOTRIOSE
ChEMBL
DrugBank
DB04268
ZINC
ZINC000098209497
PDB chain
1bb6 Chain A Residue 130 [
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Receptor-Ligand Complex Structure
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PDB
1bb6
Structural studies on the binding of 4-methylumbelliferone glycosides of chitin to rainbow trout lysozyme.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
D52 I58 N59 Y62 W63 D101 P102 A107 W108
Binding residue
(residue number reindexed from 1)
D52 I58 N59 Y62 W63 D101 P102 A107 W108
Annotation score
1
Binding affinity
MOAD
: Ka=500000M^-1
Enzymatic activity
Catalytic site (original residue number in PDB)
E35 N46 D48 S50 D52 N59
Catalytic site (residue number reindexed from 1)
E35 N46 D48 S50 D52 N59
Enzyme Commision number
3.2.1.17
: lysozyme.
Gene Ontology
Molecular Function
GO:0003796
lysozyme activity
GO:0016798
hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0031640
killing of cells of another organism
GO:0042742
defense response to bacterium
GO:0050829
defense response to Gram-negative bacterium
GO:0050830
defense response to Gram-positive bacterium
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1bb6
,
PDBe:1bb6
,
PDBj:1bb6
PDBsum
1bb6
PubMed
10089395
UniProt
P11941
|LYSC2_ONCMY Lysozyme C II
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