Structure of PDB 1b4s Chain A Binding Site BS01
Receptor Information
>1b4s Chain A (length=150) Species:
44689
(Dictyostelium discoideum) [
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VNKERTFLAVKPDGVARGLVGEIIARYEKKGFVLVGLKQLVPTKDLAESH
YAEHKERPFFGGLVSFITSGPVVAMVFEGKGVVASARLMIGVTNPLASAP
GSIRGDFGVDVGRNIIGGSDSVESANREIALWFKPEELLTEVKPNPNLYE
Ligand information
Ligand ID
PO4
InChI
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKey
NBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
Software
SMILES
CACTVS 3.341
[O-][P]([O-])([O-])=O
ACDLabs 10.04
[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0
[O-]P(=O)([O-])[O-]
Formula
O4 P
Name
PHOSPHATE ION
ChEMBL
DrugBank
DB14523
ZINC
PDB chain
1b4s Chain A Residue 161 [
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Receptor-Ligand Complex Structure
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PDB
1b4s
Nucleophilic activation by positioning in phosphoryl transfer catalyzed by nucleoside diphosphate kinase.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
K16 Y56 G122 G123
Binding residue
(residue number reindexed from 1)
K11 Y51 G117 G118
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
K16 Y56 N119 G122 E133
Catalytic site (residue number reindexed from 1)
K11 Y51 N114 G117 E128
Enzyme Commision number
2.7.4.6
: nucleoside-diphosphate kinase.
Gene Ontology
Molecular Function
GO:0004550
nucleoside diphosphate kinase activity
GO:0005524
ATP binding
GO:0016301
kinase activity
GO:0046872
metal ion binding
Biological Process
GO:0006183
GTP biosynthetic process
GO:0006187
dGTP biosynthetic process from dGDP
GO:0006228
UTP biosynthetic process
GO:0006241
CTP biosynthetic process
GO:0006414
translational elongation
GO:0007186
G protein-coupled receptor signaling pathway
GO:0009117
nucleotide metabolic process
GO:0009142
nucleoside triphosphate biosynthetic process
GO:0009617
response to bacterium
GO:0016310
phosphorylation
GO:0019954
asexual reproduction
GO:0030036
actin cytoskeleton organization
GO:0045920
negative regulation of exocytosis
GO:0048550
negative regulation of pinocytosis
GO:0050765
negative regulation of phagocytosis
Cellular Component
GO:0005737
cytoplasm
GO:0005840
ribosome
GO:0005856
cytoskeleton
GO:0005886
plasma membrane
GO:0015629
actin cytoskeleton
GO:0030141
secretory granule
GO:0045335
phagocytic vesicle
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1b4s
,
PDBe:1b4s
,
PDBj:1b4s
PDBsum
1b4s
PubMed
10200157
UniProt
P22887
|NDKC_DICDI Nucleoside diphosphate kinase, cytosolic (Gene Name=ndkC-1)
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