Structure of PDB 1az2 Chain A Binding Site BS01
Receptor Information
>1az2 Chain A (length=314) Species:
9606
(Homo sapiens) [
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SRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNE
NEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKL
DYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEG
LVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQS
KGIVVTAYSPLGSPDRPYAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRF
PMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVAALL
SCTSHKDYPFHEEF
Ligand information
Ligand ID
NAP
InChI
InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChIKey
XJLXINKUBYWONI-NNYOXOHSSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)OP(=O)(O)O)O)O)O)C(=O)N
CACTVS 3.341
NC(=O)c1ccc[n+](c1)[CH]2O[CH](CO[P]([O-])(=O)O[P](O)(=O)OC[CH]3O[CH]([CH](O[P](O)(O)=O)[CH]3O)n4cnc5c(N)ncnc45)[CH](O)[CH]2O
CACTVS 3.341
NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](CO[P]([O-])(=O)O[P@@](O)(=O)OC[C@H]3O[C@H]([C@H](O[P](O)(O)=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
OpenEye OEToolkits 1.5.0
c1cc(c[n+](c1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)([O-])O[P@](=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)n4cnc5c4ncnc5N)OP(=O)(O)O)O)O)O)C(=O)N
Formula
C21 H28 N7 O17 P3
Name
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE;
2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE
ChEMBL
CHEMBL295069
DrugBank
DB03461
ZINC
PDB chain
1az2 Chain A Residue 316 [
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Receptor-Ligand Complex Structure
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PDB
1az2
The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
Resolution
2.9 Å
Binding residue
(original residue number in PDB)
G18 T19 W20 K21 D43 Y48 H110 Q183 Y209 S210 L212 S214 P215 D216 L228 A245 I260 K262 S263 V264 T265 R268 N272
Binding residue
(residue number reindexed from 1)
G17 T18 W19 K20 D42 Y47 H109 Q182 Y208 S209 L211 S213 P214 D215 L227 A244 I259 K261 S262 V263 T264 R267 N271
Annotation score
4
Enzymatic activity
Catalytic site (original residue number in PDB)
D43 Y48 K77 H110
Catalytic site (residue number reindexed from 1)
D42 Y47 K76 H109
Enzyme Commision number
1.1.1.21
: aldose reductase.
1.1.1.300
: NADP-retinol dehydrogenase.
1.1.1.372
: D/L-glyceraldehyde reductase.
1.1.1.54
: allyl-alcohol dehydrogenase.
Gene Ontology
Molecular Function
GO:0001758
retinal dehydrogenase activity
GO:0004032
aldose reductase (NADPH) activity
GO:0005515
protein binding
GO:0009055
electron transfer activity
GO:0016491
oxidoreductase activity
GO:0036130
prostaglandin H2 endoperoxidase reductase activity
GO:0043795
glyceraldehyde oxidoreductase activity
GO:0047655
allyl-alcohol dehydrogenase activity
GO:0047939
L-glucuronate reductase activity
GO:0047956
glycerol dehydrogenase (NADP+) activity
GO:0052650
all-trans-retinol dehydrogenase (NADP+) activity
Biological Process
GO:0001523
retinoid metabolic process
GO:0002070
epithelial cell maturation
GO:0003091
renal water homeostasis
GO:0005975
carbohydrate metabolic process
GO:0006629
lipid metabolic process
GO:0006693
prostaglandin metabolic process
GO:0006700
C21-steroid hormone biosynthetic process
GO:0019853
L-ascorbic acid biosynthetic process
GO:0035809
regulation of urine volume
GO:0042572
retinol metabolic process
GO:0043066
negative regulation of apoptotic process
GO:0044597
daunorubicin metabolic process
GO:0044598
doxorubicin metabolic process
GO:0046370
fructose biosynthetic process
GO:0071475
cellular hyperosmotic salinity response
GO:0072205
metanephric collecting duct development
Cellular Component
GO:0005615
extracellular space
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005829
cytosol
GO:0070062
extracellular exosome
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Molecular Function
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Cellular Component
External links
PDB
RCSB:1az2
,
PDBe:1az2
,
PDBj:1az2
PDBsum
1az2
PubMed
9405046
UniProt
P15121
|ALDR_HUMAN Aldo-keto reductase family 1 member B1 (Gene Name=AKR1B1)
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