Structure of PDB 1ay5 Chain A Binding Site BS01
Receptor Information
>1ay5 Chain A (length=394) Species:
266
(Paracoccus denitrificans) [
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MLGNLKPQAPDKILALMGEFRADPRQGKIDLGVGVYKDATGHTPIMRAVH
AAEQRMLETETTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGG
TGALRQALELARMANPDLRVFVSDPTWPNHVSIMNFMGLPVQTYRYFDAE
TRGVDFEGMKADLAAAKKGDMVLLHGCCHNPTGANLTLDQWAEIASILEK
TGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAASCSKNFGIYRE
RTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPEL
RADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGA
TPEQVKRIKEEFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV
Ligand information
Ligand ID
PLP
InChI
InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKey
NGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0
Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04
O=P(O)(O)OCc1cnc(c(O)c1C=O)C
Formula
C8 H10 N O6 P
Name
PYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBL
CHEMBL82202
DrugBank
DB00114
ZINC
ZINC000001532514
PDB chain
1ay5 Chain A Residue 413 [
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Receptor-Ligand Complex Structure
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PDB
1ay5
Crystal structures of Paracoccus denitrificans aromatic amino acid aminotransferase: a substrate recognition site constructed by rearrangement of hydrogen bond network.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
G107 G108 T109 W140 D222 A224 Y225 S255 S257 K258 R266
Binding residue
(residue number reindexed from 1)
G99 G100 T101 W127 D208 A210 Y211 S240 S242 K243 R251
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
W140 D222 A224 K258
Catalytic site (residue number reindexed from 1)
W127 D208 A210 K243
Enzyme Commision number
2.6.1.57
: aromatic-amino-acid transaminase.
Gene Ontology
Molecular Function
GO:0004069
L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004838
L-tyrosine-2-oxoglutarate transaminase activity
GO:0008483
transaminase activity
GO:0008793
aromatic-amino-acid transaminase activity
GO:0030170
pyridoxal phosphate binding
GO:0042802
identical protein binding
GO:0080130
L-phenylalanine-2-oxoglutarate transaminase activity
Biological Process
GO:0006520
amino acid metabolic process
GO:0008652
amino acid biosynthetic process
GO:0009058
biosynthetic process
GO:0009073
aromatic amino acid family biosynthetic process
GO:0033585
L-phenylalanine biosynthetic process from chorismate via phenylpyruvate
Cellular Component
GO:0005737
cytoplasm
GO:0005829
cytosol
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1ay5
,
PDBe:1ay5
,
PDBj:1ay5
PDBsum
1ay5
PubMed
9665848
UniProt
P95468
|TYRB_PARDE Aromatic-amino-acid aminotransferase (Gene Name=tyrB)
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