Structure of PDB 1aw5 Chain A Binding Site BS01

Receptor Information
>1aw5 Chain A (length=326) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MHTAEFLETEPTEISSVLAGGYNHPLLRQWQSERQLTKNMLIFPLFISDN
PDDFTEIDSAPNINRIGVNRLKDYLKPLVAKGLRSVILFGVPLIPGTKDP
VGTAADDPAGPVIQGIRFIREKFPELYIICDVCLCEYTSHGHCGVLYDDG
TINRERSVSRLAAVAVNYAKAGAHCVAPSDMIDGRIRDIKRGLINANLAH
KTFVLSYAAKFSGNLYGPACYQLPPAGRGLARRALERDMSEGADGIIVKP
STFYLDIVRDASEICKDLPICAYHVSGEYAMLHAAAEKGVVDLKTIAFES
HQGFLRAGARLIITYLAPEFLDWLDE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1aw5 Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1aw5 X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		C133 C135 C143
Binding residue
(residue number reindexed from 1)		C133 C135 C143
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K210 K263
Catalytic site (residue number reindexed from 1) K210 K249
Enzyme Commision number 4.2.1.24: porphobilinogen synthase.
Gene Ontology
Molecular Function
GO:0004655 porphobilinogen synthase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1aw5, PDBe:1aw5, PDBj:1aw5
PDBsum1aw5
PubMed9406553
UniProtP05373|HEM2_YEAST Delta-aminolevulinic acid dehydratase (Gene Name=HEM2)

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