Structure of PDB 1avr Chain A Binding Site BS01

Receptor Information
>1avr Chain A (length=316) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQE
ISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKG
AGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRM
LVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRS
VSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLA
ETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKG
DTSGDYKKALLLLCGE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1avr Chain A Residue 321 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1avr Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		L100 G102 G104 D144 E318
Binding residue
(residue number reindexed from 1)		L98 G100 G102 D142 E316
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0043066 negative regulation of apoptotic process
GO:0050819 negative regulation of coagulation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0009897 external side of plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0042383 sarcolemma
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072563 endothelial microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1avr, PDBe:1avr, PDBj:1avr
PDBsum1avr
PubMed1311770
UniProtP08758|ANXA5_HUMAN Annexin A5 (Gene Name=ANXA5)

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