Structure of PDB 1avc Chain A Binding Site BS01

Receptor Information
>1avc Chain A (length=642) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YRGSIRDFPDFNPSQDAETLYNAMKGFGSDKEAIINLITSRSNKQRQEIC
QNYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYADAKEIKDAISGIG
TDEKCLIEILASRTNEQIHQLVAAYKDAYERDLEADITGDTSGHFRKMLV
VLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQ
HLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTAEYFAER
LFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDT
SGEYKKTLLKLCGGQFFPEAAQVAYQMWELSAVARVELKGTVRPAGDFNP
DADAKALRKAMKGLGTDEDTIIDIITHRSNAQRQQIRQTFKSHFGRDLMA
DLKSELSGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATR
TNAEIQAINKAYKEDYHKTLEDALSSDTSGHFKRILISLATGNREEGGED
RERAREDAQVAAEILTRFMMILCTRSYPDLRRVFQEFVKMTNYDVEHTIK
KEMSGDVRDVFVAIVQSVKNKPLFFADKLYKSMKGAGTEEKTLTRIMVSR
SEIDLLNIRREFIEKYDKSLHQAIEGDTSGHFLKALLAICGG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1avc Chain A Residue 674 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1avc Crystal structure of bovine annexin VI in a calcium-bound state.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		M376 G378 L379 G380 T381 E420
Binding residue
(residue number reindexed from 1)		M361 G363 L364 G365 T366 E405
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008201 heparin binding
GO:0019899 enzyme binding
GO:0035374 chondroitin sulfate binding
GO:0038024 cargo receptor activity
GO:0048306 calcium-dependent protein binding
GO:0051015 actin filament binding
Biological Process
GO:0003418 growth plate cartilage chondrocyte differentiation
GO:0006816 calcium ion transport
GO:0006937 regulation of muscle contraction
GO:0016192 vesicle-mediated transport
GO:0031214 biomineral tissue development
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051560 mitochondrial calcium ion homeostasis
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0030061 mitochondrial crista
GO:0031982 vesicle
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042584 chromaffin granule membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1avc, PDBe:1avc, PDBj:1avc
PDBsum1avc
PubMed9748523
UniProtP79134|ANXA6_BOVIN Annexin A6 (Gene Name=ANXA6)

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