Structure of PDB 1av6 Chain A Binding Site BS01

Receptor Information
>1av6 Chain A (length=289) Species: 10254 (Vaccinia virus WR) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVSLDKPFMYFEEIDNELDYEPESANEVAKKLPYQGQLKLLLGELFFLSK
LQRHGILDGATVVYIGSAPGTHIRYLRDHFYNLGVIIKWMLIDGRHHDPI
LNGLRDVTLVTRFVDEEYLRSIKKQLHPSKIILISDVRSPSTADLLSNYA
LQNVMISILNPVASSLKWRCPFPDQWIKDFYIPHGNKMLQPFAPSYSAEM
RLLSIYTGENMRLTRVTKSDAVNYEKKMYYLNKIVRNKVVVNFDYPNQEY
DYFHMYFMLRTVYCNKTFPTTKAKVLFLQQSIFRFLNIP
Ligand information
Receptor-Ligand Complex Structure
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PDB1av6 Structural basis for sequence-nonspecific recognition of 5'-capped mRNA by a cap-modifying enzyme.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		K32 Y36 G38 Q39 K41 P71 K175 E207
Binding residue
(residue number reindexed from 1)		K30 Y34 G36 Q37 K39 P69 K167 E199
Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0031440 regulation of mRNA 3'-end processing

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Molecular Function
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Biological Process
External links
PDB RCSB:1av6, PDBe:1av6, PDBj:1av6
PDBsum1av6
PubMed9660928
UniProtP07617|MCE_VACCW Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (Gene Name=OPG102)

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