Structure of PDB 1au8 Chain A Binding Site BS01
Receptor Information
>1au8 Chain A (length=224) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNI
NVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDR
QCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKS
SGVPPEVFTRVSSFLPWIRTTMRS
Ligand information
Ligand ID
0H8
InChI
InChI=1S/C19H35N4O8P/c1-12(2)17(21-14(24)8-9-16(25)26)19(28)23-11-5-6-13(23)18(27)22-15(32(29,30)31)7-3-4-10-20/h12-13,15,17H,3-11,20H2,1-2H3,(H,21,24)(H,22,27)(H,25,26)(H2,29,30,31)/t13-,15+,17-/m0/s1
InChIKey
POVVCGMAFFRCCC-LXZKKBNFSA-N
SMILES
Software
SMILES
CACTVS 3.370
CC(C)[C@H](NC(=O)CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)[P](O)(O)=O
ACDLabs 12.01
O=C(NC(CCCCN)P(=O)(O)O)C1N(C(=O)C(NC(=O)CCC(=O)O)C(C)C)CCC1
OpenEye OEToolkits 1.7.0
CC(C)C(C(=O)N1CCCC1C(=O)NC(CCCCN)P(=O)(O)O)NC(=O)CCC(=O)O
OpenEye OEToolkits 1.7.0
CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)P(=O)(O)O)NC(=O)CCC(=O)O
CACTVS 3.370
CC(C)[CH](NC(=O)CCC(O)=O)C(=O)N1CCC[CH]1C(=O)N[CH](CCCCN)[P](O)(O)=O
Formula
C19 H35 N4 O8 P
Name
N-(3-carboxypropanoyl)-L-valyl-N-[(1R)-5-amino-1-phosphonopentyl]-L-prolinamide
ChEMBL
DrugBank
ZINC
ZINC000031976560
PDB chain
1au8 Chain A Residue 1 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1au8
HUMAN CATHEPSIN G
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
H57 A190 G193 S195 S214 Y215 G216 K217 E226
Binding residue
(residue number reindexed from 1)
H44 A176 G179 S181 S196 Y197 G198 K199 E206
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)
H44 D88 K178 G179 D180 S181 G182
Enzyme Commision number
3.4.21.20
: cathepsin G.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005515
protein binding
GO:0008201
heparin binding
GO:0008233
peptidase activity
GO:0008236
serine-type peptidase activity
GO:0048018
receptor ligand activity
GO:0089720
caspase binding
Biological Process
GO:0002003
angiotensin maturation
GO:0002548
monocyte chemotaxis
GO:0006468
protein phosphorylation
GO:0006508
proteolysis
GO:0006935
chemotaxis
GO:0006955
immune response
GO:0016485
protein processing
GO:0019221
cytokine-mediated signaling pathway
GO:0019731
antibacterial humoral response
GO:0022617
extracellular matrix disassembly
GO:0030168
platelet activation
GO:0032496
response to lipopolysaccharide
GO:0035590
purinergic nucleotide receptor signaling pathway
GO:0042119
neutrophil activation
GO:0042742
defense response to bacterium
GO:0050778
positive regulation of immune response
GO:0050829
defense response to Gram-negative bacterium
GO:0050830
defense response to Gram-positive bacterium
GO:0050832
defense response to fungus
GO:0050868
negative regulation of T cell activation
GO:0070946
neutrophil-mediated killing of gram-positive bacterium
GO:0071222
cellular response to lipopolysaccharide
GO:0098786
biofilm matrix disassembly
GO:1901731
positive regulation of platelet aggregation
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005764
lysosome
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0010494
cytoplasmic stress granule
GO:0016020
membrane
GO:0030141
secretory granule
GO:0035578
azurophil granule lumen
GO:0043231
intracellular membrane-bounded organelle
GO:0062023
collagen-containing extracellular matrix
GO:0070062
extracellular exosome
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1au8
,
PDBe:1au8
,
PDBj:1au8
PDBsum
1au8
PubMed
UniProt
P08311
|CATG_HUMAN Cathepsin G (Gene Name=CTSG)
[
Back to BioLiP
]