Structure of PDB 1atn Chain A Binding Site BS01
Receptor Information
>1atn Chain A (length=372) Species:
9986
(Oryctolagus cuniculus) [
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DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQK
DSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEE
HPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTG
IVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSF
VTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITI
GNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLS
TFQQMWITKQEYDEAGPSIVHR
Ligand information
Ligand ID
ATP
InChI
InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKey
ZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341
Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04
O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
Formula
C10 H16 N5 O13 P3
Name
ADENOSINE-5'-TRIPHOSPHATE
ChEMBL
CHEMBL14249
DrugBank
DB00171
ZINC
ZINC000004261765
PDB chain
1atn Chain A Residue 375 [
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Receptor-Ligand Complex Structure
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PDB
1atn
Atomic structure of the actin:DNase I complex.
Resolution
2.8 Å
Binding residue
(original residue number in PDB)
G13 S14 G15 L16 K18 G156 D157 G158 V159 G182 K213 E214 G302 T303 Y306
Binding residue
(residue number reindexed from 1)
G13 S14 G15 L16 K18 G156 D157 G158 V159 G182 K213 E214 G302 T303 Y306
Annotation score
5
Enzymatic activity
Enzyme Commision number
3.6.4.-
Gene Ontology
Molecular Function
GO:0000287
magnesium ion binding
GO:0003785
actin monomer binding
GO:0005509
calcium ion binding
GO:0005515
protein binding
GO:0005523
tropomyosin binding
GO:0005524
ATP binding
GO:0016787
hydrolase activity
GO:0019904
protein domain specific binding
GO:0031013
troponin I binding
GO:0031432
titin binding
GO:0032036
myosin heavy chain binding
GO:0042802
identical protein binding
GO:0048306
calcium-dependent protein binding
GO:0140660
cytoskeletal motor activator activity
Biological Process
GO:0010628
positive regulation of gene expression
GO:0030041
actin filament polymerization
GO:0030240
skeletal muscle thin filament assembly
GO:0048741
skeletal muscle fiber development
GO:0051017
actin filament bundle assembly
GO:0090131
mesenchyme migration
Cellular Component
GO:0001725
stress fiber
GO:0005737
cytoplasm
GO:0005856
cytoskeleton
GO:0005865
striated muscle thin filament
GO:0005884
actin filament
GO:0030027
lamellipodium
GO:0030175
filopodium
GO:0031941
filamentous actin
GO:0032432
actin filament bundle
GO:0044297
cell body
GO:0098723
skeletal muscle myofibril
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1atn
,
PDBe:1atn
,
PDBj:1atn
PDBsum
1atn
PubMed
2395459
UniProt
P68135
|ACTS_RABIT Actin, alpha skeletal muscle (Gene Name=ACTA1)
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