Structure of PDB 1aq7 Chain A Binding Site BS01

Receptor Information

>1aq7 Chain A (length=223) Species: 9913 (Bos taurus)

IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRL
GEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRV
ASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKS
AYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK
NKPGVYTKVCNYVSWIKQTIASN

Ligand information

>1aq7 Chain B (length=4) Species: 267869 (Microcystis aeruginosa NIES-98)

tIPR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1aq7 Aeruginosins 98-A and B, Trypsin Inhibitors from the Blue-Green Alga Microcystis Aeruginosa (Nies-98)
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): H57 L99 D189 S190 C191 Q192 S214 W215 G216 G219 C220 G226
• Binding residue (residue number reindexed from 1): H40 L81 D171 S172 C173 Q174 S192 W193 G194 G196 C197 G204

Enzymatic activity

• Catalytic site (original residue number in PDB): H57 D102 Q192 G193 D194 S195 G196
• Catalytic site (residue number reindexed from 1): H40 D84 Q174 G175 D176 S177 G178
• Enzyme Commision number: 3.4.21.4: trypsin.

Gene Ontology

Molecular Function

• GO:0004175 endopeptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0005515 protein binding
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding
• GO:0097655 serpin family protein binding

Biological Process

• GO:0006508 proteolysis
• GO:0007586 digestion

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0097180 serine protease inhibitor complex

External links

• PDB: RCSB:1aq7, PDBe:1aq7, PDBj:1aq7
• PDBsum: 1aq7
• UniProt: P00760|TRY1_BOVIN Serine protease 1 (Gene Name=PRSS1)