Structure of PDB 1ann Chain A Binding Site BS01

Receptor Information
>1ann Chain A (length=315) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGTVKAASGFNAAEDAQTLRKAMKGLGTDEDAIINVLAYRSTAQRQEIRT
AYKTTIGRDLMDDLKSELSGNFEQVILGMMTPTVLYDVQELRKAMKGAGT
DEGCLIEILASRTPEEIRRINQTYQLQYGRSLEDDIRSDTSFMFQRVLVS
LSAGGRDESNYLDDALMRQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNH
LLHVFDEYKRIAQKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAERL
YKSMKGLGTDDDTLIRVMVSRAEIDMLDIRANFKRLYGKSLYSFIKGDTS
GDYRKVLLILCGGDD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1ann Chain A Residue 319 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ann Three Dimensional Structure of Annexin IV
Resolution2.3 Å
Binding residue
(original residue number in PDB)		M257 G259 G261 D301
Binding residue
(residue number reindexed from 1)		M254 G256 G258 D298
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008201 heparin binding
GO:0030246 carbohydrate binding
GO:0035374 chondroitin sulfate binding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0042584 chromaffin granule membrane
GO:0042589 zymogen granule membrane

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1ann, PDBe:1ann, PDBj:1ann
PDBsum1ann
PubMed
UniProtP13214|ANXA4_BOVIN Annexin A4 (Gene Name=ANXA4)

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