Structure of PDB 1alc Chain A Binding Site BS01

Receptor Information

>1alc Chain A (length=122) Species: 9556 (Papio cynocephalus)

KQFTKCELSQNLYDIDGYGRIALPELICTMFHTSGYDTQAIVENDESTEY
GLFQISNALWCKSSQSPQSRNICDITCDKFLDDDITDDIMCAKKILDIKG
IDYWIAHKALCTEKLEQWLCEK

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1alc Chain A Residue 200

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1alc Refined structure of baboon alpha-lactalbumin at 1.7 A resolution. Comparison with C-type lysozyme.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): K79 D82 D84 D87 D88
• Binding residue (residue number reindexed from 1): K79 D82 D84 D87 D88
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): T33 D45 S47 E49 S56
• Catalytic site (residue number reindexed from 1): T33 D45 S47 E49 S56

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0004461 lactose synthase activity
• GO:0005509 calcium ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0005989 lactose biosynthetic process
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1alc, PDBe:1alc, PDBj:1alc
• PDBsum: 1alc
• PubMed: 2769757
• UniProt: P12065|LALBA_PAPCY Alpha-lactalbumin (Gene Name=LALBA)