Structure of PDB 1adj Chain A Binding Site BS01
Receptor Information
>1adj Chain A (length=420) Species:
274
(Thermus thermophilus) [
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TARAVRGTKDLFGKELRMHQRIVATARKVLEAAGALELVTPIFEETQVFE
KGVGAATDIVRKEMFTFQDRGGRSLTLRPEGTAAMVRAYLEHGMKVWPQP
VRLWMAGPMFRAERPQKGRYRQFHQVNYEALGSENPILDAEAVVLLYECL
KELGLRRLKVKLSSVGDPEDRARYNAYLREVLSPHREALSEDSKERLEEN
PMRILDSKSERDQALLKELGVRPMLDFLGEEARAHLKEVERHLERLSVPY
ELEPALVRGLDYYVRTAFEVHHEEIGAQSALGGGGRYDGLSELLGGPRVP
GVGFAFGVERVALALEAEGFGLPEEKGPDLYLIPLTEEAVAEAFYLAEAL
RPRLRAEYALAPRKPAKGLEEALKRGAAFAGFLGEDELRAGEVTLKRLAT
GEQVRLSREEVPGYLLQALG
Ligand information
Ligand ID
HIS
InChI
InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/p+1/t5-/m0/s1
InChIKey
HNDVDQJCIGZPNO-YFKPBYRVSA-O
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
c1c([nH+]c[nH]1)CC(C(=O)O)N
CACTVS 3.341
N[CH](Cc1c[nH]c[nH+]1)C(O)=O
CACTVS 3.341
N[C@@H](Cc1c[nH]c[nH+]1)C(O)=O
ACDLabs 10.04
O=C(O)C(N)Cc1cnc[nH+]1
OpenEye OEToolkits 1.5.0
c1c([nH+]c[nH]1)C[C@@H](C(=O)O)N
Formula
C6 H10 N3 O2
Name
HISTIDINE
ChEMBL
DrugBank
ZINC
PDB chain
1adj Chain A Residue 423 [
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Receptor-Ligand Complex Structure
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PDB
1adj
Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
E81 T83 E130 Y263 Y264 Y288 G304 F305
Binding residue
(residue number reindexed from 1)
E80 T82 E129 Y262 Y263 Y287 G303 F304
Annotation score
5
Enzymatic activity
Enzyme Commision number
6.1.1.21
: histidine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0004812
aminoacyl-tRNA ligase activity
GO:0004821
histidine-tRNA ligase activity
GO:0005524
ATP binding
Biological Process
GO:0006412
translation
GO:0006427
histidyl-tRNA aminoacylation
Cellular Component
GO:0005737
cytoplasm
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1adj
,
PDBe:1adj
,
PDBj:1adj
PDBsum
1adj
PubMed
9115984
UniProt
P56194
|SYH_THET8 Histidine--tRNA ligase (Gene Name=hisS)
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