Structure of PDB 1ad5 Chain A Binding Site BS01

Receptor Information

>1ad5 Chain A (length=438) Species: 9606 (Homo sapiens)

EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYI
PSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKG
SYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKK
GNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWM
ATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP
IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI
HRDLRAANILVSASLVCKIADFGLARVGAKFPIKWTAPEAINFGSFTIKS
DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYN
IMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1ad5 Chain A Residue 3

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ad5 Crystal structure of the Src family tyrosine kinase Hck.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): N391 D404
• Binding residue (residue number reindexed from 1): N308 D321
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D386 R388 A390 N391 D404 G406 P425
• Catalytic site (residue number reindexed from 1): D303 R305 A307 N308 D321 G323 P332
• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:1ad5, PDBe:1ad5, PDBj:1ad5
• PDBsum: 1ad5
• PubMed: 9024658
• UniProt: P08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)