Structure of PDB 1aa9 Chain A Binding Site BS01
Receptor Information
>1aa9 Chain A (length=171) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQHKLRKL
Ligand information
Ligand ID
MG
InChI
InChI=1S/Mg/q+2
InChIKey
JLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mg+2]
CACTVS 3.341
[Mg++]
Formula
Mg
Name
MAGNESIUM ION
ChEMBL
DrugBank
DB01378
ZINC
PDB chain
1aa9 Chain A Residue 173 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1aa9
Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein.
Resolution
N/A
Binding residue
(original residue number in PDB)
S17 Y32 D33
Binding residue
(residue number reindexed from 1)
S17 Y32 D33
Annotation score
1
Enzymatic activity
Enzyme Commision number
3.6.5.2
: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924
GTPase activity
GO:0003925
G protein activity
GO:0005515
protein binding
GO:0005525
GTP binding
GO:0016787
hydrolase activity
GO:0019003
GDP binding
GO:0043495
protein-membrane adaptor activity
GO:0160185
phospholipase C activator activity
Biological Process
GO:0000165
MAPK cascade
GO:0001934
positive regulation of protein phosphorylation
GO:0006357
regulation of transcription by RNA polymerase II
GO:0006897
endocytosis
GO:0006935
chemotaxis
GO:0007165
signal transduction
GO:0007166
cell surface receptor signaling pathway
GO:0007264
small GTPase-mediated signal transduction
GO:0007265
Ras protein signal transduction
GO:0008284
positive regulation of cell population proliferation
GO:0008285
negative regulation of cell population proliferation
GO:0008286
insulin receptor signaling pathway
GO:0009887
animal organ morphogenesis
GO:0010628
positive regulation of gene expression
GO:0010629
negative regulation of gene expression
GO:0014044
Schwann cell development
GO:0030335
positive regulation of cell migration
GO:0032729
positive regulation of type II interferon production
GO:0032956
regulation of actin cytoskeleton organization
GO:0034260
negative regulation of GTPase activity
GO:0042088
T-helper 1 type immune response
GO:0042127
regulation of cell population proliferation
GO:0042552
myelination
GO:0042832
defense response to protozoan
GO:0043406
positive regulation of MAP kinase activity
GO:0043410
positive regulation of MAPK cascade
GO:0043524
negative regulation of neuron apoptotic process
GO:0043547
positive regulation of GTPase activity
GO:0045944
positive regulation of transcription by RNA polymerase II
GO:0046330
positive regulation of JNK cascade
GO:0048144
fibroblast proliferation
GO:0048146
positive regulation of fibroblast proliferation
GO:0048169
regulation of long-term neuronal synaptic plasticity
GO:0050679
positive regulation of epithelial cell proliferation
GO:0050852
T cell receptor signaling pathway
GO:0051402
neuron apoptotic process
GO:0051726
regulation of cell cycle
GO:0060612
adipose tissue development
GO:0070374
positive regulation of ERK1 and ERK2 cascade
GO:0071480
cellular response to gamma radiation
GO:0090303
positive regulation of wound healing
GO:0090314
positive regulation of protein targeting to membrane
GO:0090398
cellular senescence
GO:0090402
oncogene-induced cell senescence
GO:0097193
intrinsic apoptotic signaling pathway
GO:0098696
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:1900029
positive regulation of ruffle assembly
GO:2000630
positive regulation of miRNA metabolic process
Cellular Component
GO:0000139
Golgi membrane
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005789
endoplasmic reticulum membrane
GO:0005794
Golgi apparatus
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0016020
membrane
GO:0048471
perinuclear region of cytoplasm
GO:0098978
glutamatergic synapse
GO:1905360
GTPase complex
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1aa9
,
PDBe:1aa9
,
PDBj:1aa9
PDBsum
1aa9
PubMed
9230043
UniProt
P01112
|RASH_HUMAN GTPase HRas (Gene Name=HRAS)
[
Back to BioLiP
]