Structure of PDB 1a8h Chain A Binding Site BS01

Receptor Information
>1a8h Chain A (length=500) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEKVFYVTTPIYYVNAEPHLGHAYTTVVADFLARWHRLDGYRTFFLTGTD
EHGETVYRAAQAAGEDPKAFVDRVSGRFKRAWDLLGIAYDDFIRTTEERH
KKVVQLVLKKVYEAGDIYYGEYEGLYCVSCERFYTEKELVEGLCPIHGRP
VERRKEGNYFFRMEKYRPWLQEYIQENPDLIRPEGYRNEVLAMLAEPIGD
LSISRPKSRVPWGIPLPWDENHVTYVWFDALLNYVSALDYPEGEAYRTFW
PHAWHLIGKDILKPHAVFWPTMLKAAGIPMYRHLNVGGFLLGPDGRKMSK
TLGNVVDPFALLEKYGRDALRYYLLREIPYGQDTPVSEEALRTRYEADLA
DDLGNLVQRTRAMLFRFAEGRIPEPVAGEELAEGTGLAGRLRPLVRELKF
HVALEEAMAYVKALNRYINEKKPWELFKKEPEEARAVLYRVVEGLRIASI
LLTPAMPDKMAELRRALGLKEEVRLEEAERWGLAEPRPIPEEAPVLFPKK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1a8h Chain A Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1a8h The 2.0 A crystal structure of Thermus thermophilus methionyl-tRNA synthetase reveals two RNA-binding modules.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		C127 C130 C144 H147
Binding residue
(residue number reindexed from 1)		C127 C130 C144 H147
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H19 H22 D50 C127 C130 C144 H147 K297 K300
Catalytic site (residue number reindexed from 1) H19 H22 D50 C127 C130 C144 H147 K297 K300
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1a8h, PDBe:1a8h, PDBj:1a8h
PDBsum1a8h
PubMed10673435
UniProtP23395|SYM_THET8 Methionine--tRNA ligase (Gene Name=metG)

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