Structure of PDB 1a8b Chain A Binding Site BS01
Receptor Information
>1a8b Chain A (length=318) Species:
10116
(Rattus norvegicus) [
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ALRGTVTDFSGFDGRADAEVLRKAMKGLGTDEDSILNLLTARSNAQRQQI
AEEFKTLFGRDLVNDMKSELTGKFEKLIVALMKPSRLYDAYELKHALKGA
GTDEKVLTEIIASRTPEELRAIKQAYEEEYGSNLEDDVVGDTSGYYQRML
VVLLQANRDPDTAIDDAQVELDAQALFQAGELKWGTDEEKFITILGTRSV
SHLRRVFDKYMTISGFQIEETIDRETSGNLENLLLAVVKSIRSIPAYLAE
TLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRKNFATSLYSMIKGD
TSGDYKKALLLLCGGEDD
Ligand information
Ligand ID
CA
InChI
InChI=1S/Ca/q+2
InChIKey
BHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
Formula
Ca
Name
CALCIUM ION
ChEMBL
DrugBank
DB14577
ZINC
PDB chain
1a8b Chain A Residue 401 [
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Receptor-Ligand Complex Structure
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PDB
1a8b
Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
M26 G28 G30 E70
Binding residue
(residue number reindexed from 1)
M25 G27 G29 E69
Annotation score
5
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0001786
phosphatidylserine binding
GO:0005388
P-type calcium transporter activity
GO:0005509
calcium ion binding
GO:0005515
protein binding
GO:0005543
phospholipid binding
GO:0005544
calcium-dependent phospholipid binding
GO:0017046
peptide hormone binding
GO:0030971
receptor tyrosine kinase binding
GO:0042802
identical protein binding
Biological Process
GO:0007596
blood coagulation
GO:0030195
negative regulation of blood coagulation
GO:0043065
positive regulation of apoptotic process
GO:0050819
negative regulation of coagulation
GO:0051592
response to calcium ion
GO:0070588
calcium ion transmembrane transport
GO:0071284
cellular response to lead ion
GO:0097066
response to thyroid hormone
GO:0097211
cellular response to gonadotropin-releasing hormone
GO:1901317
regulation of flagellated sperm motility
GO:1902721
negative regulation of prolactin secretion
Cellular Component
GO:0005615
extracellular space
GO:0005737
cytoplasm
GO:0008021
synaptic vesicle
GO:0009897
external side of plasma membrane
GO:0012506
vesicle membrane
GO:0014704
intercalated disc
GO:0030018
Z disc
GO:0030425
dendrite
GO:0030672
synaptic vesicle membrane
GO:0042383
sarcolemma
GO:0042995
cell projection
GO:0043025
neuronal cell body
GO:0043204
perikaryon
GO:0043679
axon terminus
GO:0072563
endothelial microparticle
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1a8b
,
PDBe:1a8b
,
PDBj:1a8b
PDBsum
1a8b
PubMed
7583670
UniProt
P14668
|ANXA5_RAT Annexin A5 (Gene Name=Anxa5)
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