Structure of PDB 1a77 Chain A Binding Site BS01

Receptor Information
>1a77 Chain A (length=315) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVQFGDFIPKNIISFEDLKGKKVAIDGMNALYQFLTSIRLRDGSPLRNRK
GEITSAYNGVFYKTIHLLENDITPIWVFDGEPPKLKEKTRKVRREMKEKA
ELKMKEAIKKEDFEEAAKYAKRVSYLTPKMVENCKYLLSLMGIPYVEAPS
EGEAQASYMAKKGDVWAVVSQDYDALLYGAPRVVRNLTTTKEMPELIELN
EVLEDLRISLDDLIDIAIFMGTDYNPGGVKGIGFKRAYELVRSGVAKDVL
KKEVEYYDEIKRIFKEPKVTDNYSLSLKLPDKEGIIKFLVDENDFNYDRV
KKHVDKLYNLIANKT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1a77 Chain A Residue 341 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1a77 The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		D175 D224
Binding residue
(residue number reindexed from 1)		D174 D223
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0043137 DNA replication, removal of RNA primer

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Molecular Function
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Biological Process
External links
PDB RCSB:1a77, PDBe:1a77, PDBj:1a77
PDBsum1a77
PubMed9699635
UniProtQ58839|FEN_METJA Flap endonuclease 1 (Gene Name=fen)

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