Structure of PDB 1a37 Chain A Binding Site BS01
Receptor Information
>1a37 Chain A (length=195) Species:
9913
(Bos taurus) [
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MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKN
VVGARRSSWRVVSSIEQEKKQQMAREYREKIETELRDICNDVLSLLEKFL
IPNAAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISK
IRLGLALNFSVFYYACSLAKTAFDEAIADDSTLIMQLLRDNLTLW
Ligand information
>1a37 Chain P (length=7) [
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RSTSTPN
Receptor-Ligand Complex Structure
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PDB
1a37
14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
Resolution
3.6 Å
Binding residue
(original residue number in PDB)
K49 R56 R127 Y128 L172 N173
Binding residue
(residue number reindexed from 1)
K49 R56 R120 Y121 L157 N158
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0050815
phosphoserine residue binding
GO:0140311
protein sequestering activity
Biological Process
GO:0006468
protein phosphorylation
GO:0007165
signal transduction
GO:0008104
protein localization
GO:0070372
regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737
cytoplasm
GO:0042470
melanosome
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1a37
,
PDBe:1a37
,
PDBj:1a37
PDBsum
1a37
PubMed
9632691
UniProt
P63103
|1433Z_BOVIN 14-3-3 protein zeta/delta (Gene Name=YWHAZ)
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