Structure of PDB 1a37 Chain A Binding Site BS01

Receptor Information
>1a37 Chain A (length=195) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKN
VVGARRSSWRVVSSIEQEKKQQMAREYREKIETELRDICNDVLSLLEKFL
IPNAAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISK
IRLGLALNFSVFYYACSLAKTAFDEAIADDSTLIMQLLRDNLTLW
Ligand information
Receptor-Ligand Complex Structure
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PDB1a37 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
Resolution3.6 Å
Binding residue
(original residue number in PDB)
K49 R56 R127 Y128 L172 N173
Binding residue
(residue number reindexed from 1)
K49 R56 R120 Y121 L157 N158
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0050815 phosphoserine residue binding
GO:0140311 protein sequestering activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0008104 protein localization
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
GO:0042470 melanosome

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Molecular Function

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Cellular Component
External links
PDB RCSB:1a37, PDBe:1a37, PDBj:1a37
PDBsum1a37
PubMed9632691
UniProtP63103|1433Z_BOVIN 14-3-3 protein zeta/delta (Gene Name=YWHAZ)

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