Structure of PDB 1a35 Chain A Binding Site BS01

Receptor Information
>1a35 Chain A (length=474) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKML
DHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTE
ARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGR
GNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLV
SWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYRED
WKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL
HPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL
FDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPA
KILSYNRANRAVAILCNHQRAQIALGTSKLNFLDPRITVAWCKKWGVPIE
KIYNKTQREKFAWAIDMADEDYEF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1a35 Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R364 T411 W412 I424 Y426 M428 K439 K443 R488 H632 Q633 R634 A635 T718 F723
Binding residue
(residue number reindexed from 1)		R150 T197 W198 I210 Y212 M214 K225 K229 R274 H418 Q419 R420 A421 T427 F432
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1a35, PDBe:1a35, PDBj:1a35
PDBsum1a35
PubMed9488644
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

[Back to BioLiP]