Structure of PDB 1a2b Chain A Binding Site BS01
Receptor Information
>1a2b Chain A (length=178) Species:
9606
(Homo sapiens) [
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IRKKLVIVGDVACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQV
ELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEV
KHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGA
FGYMECSAKTKDGVREVFEMATRAALQA
Ligand information
Ligand ID
MG
InChI
InChI=1S/Mg/q+2
InChIKey
JLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mg+2]
CACTVS 3.341
[Mg++]
Formula
Mg
Name
MAGNESIUM ION
ChEMBL
DrugBank
DB01378
ZINC
PDB chain
1a2b Chain A Residue 550 [
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Receptor-Ligand Complex Structure
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PDB
1a2b
Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
T19 T37
Binding residue
(residue number reindexed from 1)
T16 T34
Annotation score
1
Enzymatic activity
Enzyme Commision number
3.6.5.2
: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924
GTPase activity
GO:0003925
G protein activity
GO:0005515
protein binding
GO:0005525
GTP binding
GO:0016787
hydrolase activity
GO:0017022
myosin binding
GO:0019901
protein kinase binding
Biological Process
GO:0000902
cell morphogenesis
GO:0001764
neuron migration
GO:0001822
kidney development
GO:0001998
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0002363
alpha-beta T cell lineage commitment
GO:0003100
regulation of systemic arterial blood pressure by endothelin
GO:0003189
aortic valve formation
GO:0006357
regulation of transcription by RNA polymerase II
GO:0007010
cytoskeleton organization
GO:0007155
cell adhesion
GO:0007160
cell-matrix adhesion
GO:0007264
small GTPase-mediated signal transduction
GO:0007266
Rho protein signal transduction
GO:0007519
skeletal muscle tissue development
GO:0010812
negative regulation of cell-substrate adhesion
GO:0010975
regulation of neuron projection development
GO:0016477
cell migration
GO:0021762
substantia nigra development
GO:0021795
cerebral cortex cell migration
GO:0021861
forebrain radial glial cell differentiation
GO:0030036
actin cytoskeleton organization
GO:0030154
cell differentiation
GO:0030334
regulation of cell migration
GO:0030521
androgen receptor signaling pathway
GO:0031122
cytoplasmic microtubule organization
GO:0032467
positive regulation of cytokinesis
GO:0032956
regulation of actin cytoskeleton organization
GO:0033144
negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033688
regulation of osteoblast proliferation
GO:0034329
cell junction assembly
GO:0034446
substrate adhesion-dependent cell spreading
GO:0035385
Roundabout signaling pathway
GO:0036089
cleavage furrow formation
GO:0038027
apolipoprotein A-I-mediated signaling pathway
GO:0042476
odontogenesis
GO:0043123
positive regulation of canonical NF-kappaB signal transduction
GO:0043149
stress fiber assembly
GO:0043297
apical junction assembly
GO:0043366
beta selection
GO:0043542
endothelial cell migration
GO:0043931
ossification involved in bone maturation
GO:0044319
wound healing, spreading of cells
GO:0045198
establishment of epithelial cell apical/basal polarity
GO:0045666
positive regulation of neuron differentiation
GO:0045792
negative regulation of cell size
GO:0046638
positive regulation of alpha-beta T cell differentiation
GO:0050919
negative chemotaxis
GO:0051301
cell division
GO:0051496
positive regulation of stress fiber assembly
GO:0051893
regulation of focal adhesion assembly
GO:0060071
Wnt signaling pathway, planar cell polarity pathway
GO:0060193
positive regulation of lipase activity
GO:0061430
bone trabecula morphogenesis
GO:0070507
regulation of microtubule cytoskeleton organization
GO:0071222
cellular response to lipopolysaccharide
GO:0071345
cellular response to cytokine stimulus
GO:0071526
semaphorin-plexin signaling pathway
GO:0071803
positive regulation of podosome assembly
GO:0071902
positive regulation of protein serine/threonine kinase activity
GO:0090051
negative regulation of cell migration involved in sprouting angiogenesis
GO:0090307
mitotic spindle assembly
GO:0090324
negative regulation of oxidative phosphorylation
GO:0097049
motor neuron apoptotic process
GO:0097498
endothelial tube lumen extension
GO:0099159
regulation of modification of postsynaptic structure
GO:1901224
positive regulation of non-canonical NF-kappaB signal transduction
GO:1902766
skeletal muscle satellite cell migration
GO:1903427
negative regulation of reactive oxygen species biosynthetic process
GO:1903673
mitotic cleavage furrow formation
GO:1904695
positive regulation of vascular associated smooth muscle contraction
GO:1904996
positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1905274
regulation of modification of postsynaptic actin cytoskeleton
GO:1990869
cellular response to chemokine
GO:2000177
regulation of neural precursor cell proliferation
GO:2000406
positive regulation of T cell migration
GO:2000672
negative regulation of motor neuron apoptotic process
Cellular Component
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005768
endosome
GO:0005789
endoplasmic reticulum membrane
GO:0005829
cytosol
GO:0005856
cytoskeleton
GO:0005886
plasma membrane
GO:0005925
focal adhesion
GO:0005938
cell cortex
GO:0009898
cytoplasmic side of plasma membrane
GO:0030027
lamellipodium
GO:0030054
cell junction
GO:0030425
dendrite
GO:0030496
midbody
GO:0030667
secretory granule membrane
GO:0031982
vesicle
GO:0032154
cleavage furrow
GO:0032587
ruffle membrane
GO:0042995
cell projection
GO:0043197
dendritic spine
GO:0043296
apical junction complex
GO:0070062
extracellular exosome
GO:0071944
cell periphery
GO:0098794
postsynapse
GO:0098978
glutamatergic synapse
GO:0101003
ficolin-1-rich granule membrane
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1a2b
,
PDBe:1a2b
,
PDBj:1a2b
PDBsum
1a2b
PubMed
9545299
UniProt
P61586
|RHOA_HUMAN Transforming protein RhoA (Gene Name=RHOA)
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