Structure of PDB 1a25 Chain A Binding Site BS01

Receptor Information
>1a25 Chain A (length=132) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS
ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFM
GSLSFGISELQKAGVDGWFKLLSQEEGEYFNV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1a25 Chain A Residue 290 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1a25 Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D187 D193 D246 W247 D248
Binding residue
(residue number reindexed from 1)		D31 D37 D90 W91 D92
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
External links
PDB RCSB:1a25, PDBe:1a25, PDBj:1a25
PDBsum1a25
PubMed9817842
UniProtP68403|KPCB_RAT Protein kinase C beta type (Gene Name=Prkcb)

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