Structure of PDB 1a1r Chain A Binding Site BS01
Receptor Information
>1a1r Chain A (length=152) [
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VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPTGHAVGLFRAAVCTRGVAKAVDFIPVENLETT
MR
Ligand information
>1a1r Chain C (length=16) [
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GSVVIVGRIVLSGKPA
Receptor-Ligand Complex Structure
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PDB
1a1r
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
V55 G57 E58 V59 Q60 I61 V62 S63 T89 I90 A91 P114 G116
Binding residue
(residue number reindexed from 1)
V1 G3 E4 V5 Q6 I7 V8 S9 T35 I36 A37 P60 G62
Enzymatic activity
Catalytic site (original residue number in PDB)
H83 D107 G163 S165
Catalytic site (residue number reindexed from 1)
H29 D53 G109 S111
Enzyme Commision number
2.7.7.48
: RNA-directed RNA polymerase.
3.4.21.98
: hepacivirin.
3.4.22.-
3.6.1.15
: nucleoside-triphosphate phosphatase.
3.6.4.13
: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236
serine-type peptidase activity
Biological Process
GO:0006508
proteolysis
GO:0019087
transformation of host cell by virus
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Molecular Function
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Biological Process
External links
PDB
RCSB:1a1r
,
PDBe:1a1r
,
PDBj:1a1r
PDBsum
1a1r
PubMed
8861917
UniProt
P27958
|POLG_HCV77 Genome polyprotein
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