Structure of PDB 7qh7 Chain 9 Binding Site BS01

Receptor Information

>7qh7 Chain 9 (length=117) Species: 9606 (Homo sapiens)

ADRMSKWTSKRGPRSFRGRKGRGAKGIGFLTSGWRFVQIKEMVPEFVVPD
LTGFKLKPYVSYLAPESEETPLTAAQLFSEAVAPAIEKDFKDNLEKYGFE
PTQEGKLFQLYPRNFLR

Ligand information

>7qh7 Chain A (length=1256)

gcuaaaccuagccccaaacccccaccuuacuaccacaacuuagccaaacc
auuuacauaaaguauaggcgauagaaauugauggcgcaauagauauagua
ccgcaagggaaagacaagcauaauauagcaaggacuaaccccuauaccuu
cugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaa
gacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacaccc
gucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccu
accgagccuggugauagcugguuguccaagauagaaucuuaguucaacuu
uaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuagucca
aagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaa
aaaaugaucccaaacauauaacugaacuccucacacccaauuggaccaau
cuaucauauagaagaacuaauguuaguauaaguaacaugaaaacauucuc
cuccgcauaagccugcgucagaucugacaauuaacagcccaauaucuaca
aucaaccaacaaguuauuacccucacugucaacccaaccaggcaugcuca
uaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgcc
uguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgcc
uccuuaaauaggcuccacgaggguucagcugucucuuacuuuuaaccagu
gaaauugaccugcccgugaggcgggcauaacacagcaagacgaagacccu
auggagcuuuaauuuauuaaugcaaaaccugcauuaaaaauuucgguugg
ggcgaccucggagcagaacccaaccuccgaggcuaagacuucaccaguca
aagcgaagauccaauaacuugaccaacggaacaaguuacccuagggcaau
ccuauucuagaguccauaucaacaauaggguuuacuggaucaggacaucc
cgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccu
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
auuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagc
gccuucuaaaugauaucaucucaacuuaauacccacacccacccaagaac
aggguu

<<<.......<<<<...............................<....
..>.....<.....<<.....>>....>....>>.>>.............
<<....>>........>>>...........<<<.......>>>...<.<<
......>>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>
>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<
..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>.
.....>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<
<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<
<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...
<.....................>...>>>>>>........>>>>>>...<
<<<<...>>>>>.........>>>>>><......<<..<<<....>>><<
<<..<<<<........<<<<<..>>>>>......<<<...<<<<......
..............>>>>.......>>>.....<<.....>>.>>>>...
..>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..
<<<.........>>>...<<<<<<.............>>>>>>.......
.<<<.....>>>.....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>
.....>.....<<<<<.....>>>>>.......<<..<<<.<<...<<<<
<.<<<<<<..<<<<..<<<<<<<<.....>>>>>>>.>>>>>..<<<<..
...>>>><<<<<<...........>>>>>>.<<<..<<<<.....>>>>.
.>>>.......<<<....>>>............>>>>..>>>>>>>...<
<<<<<<...<<.......>>...>>>>>>>.....<<<<..<<<<<..<<
.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>
.....>>>>......<<<<<<<....>>>.>>>>....>>..>>>.>>..
<<<.<<<.................>>>.>>><<<<<...<<<....>>>.
>>>>>.<<<................>>>............<<<<......
.>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qh7 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): R17 S23 K24 R25 P27 R28 S29 F30 R31 G32 R33 K34 R36 K39 I41 L44 G47 W48 R49 F50 V51 Q52
• Binding residue (residue number reindexed from 1): R3 S9 K10 R11 P13 R14 S15 F16 R17 G18 R19 K20 R22 K25 I27 L30 G33 W34 R35 F36 V37 Q38

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0006915 apoptotic process
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qh7, PDBe:7qh7, PDBj:7qh7
• PDBsum: 7qh7
• PubMed: 35177605
• UniProt: Q8IXM3|RM41_HUMAN Large ribosomal subunit protein mL41 (Gene Name=MRPL41)