Structure of PDB 7qh6 Chain 9 Binding Site BS01

Receptor Information

>7qh6 Chain 9 (length=117) Species: 9606 (Homo sapiens)

ADRMSKWTSKRGPRSFRGRKGRGAKGIGFLTSGWRFVQIKEMVPEFVVPD
LTGFKLKPYVSYLAPESEETPLTAAQLFSEAVAPAIEKDFKDNLEKYGFE
PTQEGKLFQLYPRNFLR

Ligand information

>7qh6 Chain A (length=1133)

gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaagauu
uauagguagaggcgacaaaccuaccgagccuggugauagcugguugucca
agauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccu
uguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuagga
aaaaaccuuguagagagaguaaaaaauuaucccaaacauauaacugaacu
ccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguua
guauaaguaacaugaaaacauucuccuccgcauaagccugcgucagacug
acaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccu
cacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaagua
aaaggaaaaucuuaccuguuuaccaaaaacaucaccucuagcaucaccag
uauuagaggcaccgcccagcugucucuuacuuuuaaccagugaaauugac
cugcccgugaagaggcgggcauaacacagcaagacgagaagacccuaugg
agcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggc
gaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucacc
agucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguu
acccuagggauaacagcgcaauccuaauaggguuuacgguucagaccgga
guaauccaggucgguuaucuacuuuauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuagauacccacacccaagaacaggguu

<<<.......<<<<...............................<....
..>.....<.....<<.....>>....>..>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..........>>
>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<
<....<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>....
.>>>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>.<.<<<.
.....>>>.>..<<<.<<<...<.....................>...>>
>>>>........>>>>>>...<<<<<......>>>>>.........>>>>
>><......<<..<<<....>>><<<<..<<<<........<<<<<.>>>
>>......<<<...<<<<.......................>>>>.....
..>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<
<.<<.............<<.........>>....<<<<<<..........
...>>>>>>..............>>.>>>>>>>>>>>>.>>.....>...
..<<<<<........>>>>>.......<<..<<<.........<<<<.<<
<<<<..<<<<..<<<<<<<<......>>>>>>>>.>>>>..<<<<.....
>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....
>>>>..>>>....>>.........<<<....>>>............>>>>
..>>>>>>........<<..<<<<<...>>>>..>.>>.....<<<<<<<
....>>>.>>>>.....>>>.>>..<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>.......<<...........
.....>>..........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qh6 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
• Resolution: 3.08 Å
• Binding residue (original residue number in PDB): D16 R17 S23 K24 R25 P27 R28 S29 F30 R31 G32 R33 K34 K39 L44 S46 W48 R49 F50 V51 Q52
• Binding residue (residue number reindexed from 1): D2 R3 S9 K10 R11 P13 R14 S15 F16 R17 G18 R19 K20 K25 L30 S32 W34 R35 F36 V37 Q38

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0006915 apoptotic process
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qh6, PDBe:7qh6, PDBj:7qh6
• PDBsum: 7qh6
• PubMed: 35177605
• UniProt: Q8IXM3|RM41_HUMAN Large ribosomal subunit protein mL41 (Gene Name=MRPL41)