Structure of PDB 7of3 Chain 9 Binding Site BS01

Receptor Information

>7of3 Chain 9 (length=117) Species: 9606 (Homo sapiens)

ADRMSKWTSKRGPRSFRGRKGRGAKGIGFLTSGWRFVQIKEMVPEFVVPD
LTGFKLKPYVSYLAPESEETPLTAAQLFSEAVAPAIEKDFKDNLEKYGFE
PTQEGKLFQLYPRNFLR

Ligand information

>7of3 Chain A (length=1386)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacccaaauaaaguauaggcgauagaaauugaaauggcgcaauag
auauaguaccgcaagggaaagaugaaaaacaagcauaauauagcaaggac
uaaccccuauaccuucugcaaugaauuaacuagaaauaacuuugcaagga
gagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcua
aaagagcacacccgucuauguagcaaaauagugggaagauuuauagguag
aggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaau
cuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccuuccuuaaauaggga
uggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugac
cugcccgugagaggcgggcauaacacagcaagacgagagacccuauggag
cuuuaauuuauuaaugcaaacaaccugcauuaaaaauuucgguuggggcg
accucggagcagaacccaaccuccgagcaguacaugcuaagacuucacca
gucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguua
cccuagggaaauccuauucuagaguccauaucaacaauaggguuuacgac
cucguuggaucaggacaucccgauggugcagccgcuauuaaagguucguu
uguucaacgauuaaaguccuacgugaucugaguucagaccggaguaaucc
aggucgguuucuaucuacuuuaauuccucccuguacgaaaggacaagaga
aauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucuca
acuuaguauuauacccacacacccaagaacaggguu

<<<.......<<<<.................................<..
....>...............<<.....>>...........>>.>>.....
........<<....>>...............>>>...........<<<..
.....>>>...<.<<....>>.>.<<<<<<.........<<<.<<..<<.
...>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.
....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>..
.<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<
....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<....[.>>>>>>>>>>...<<<......>>>
....<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>>.......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<.<<<<.....>>>>.
.>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.........
..<<<<<.......>>>>>.......<<..<<<.<<<...<<<<<.<<<<
<<..<<<<<.<<<<<<<<.......>>>>>>>>>>>>>..<<<<((((.>
>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>
>>>..>>>....>>.........<<<....>>>............>>>>.
.>>>>>>>.<<<<<<<<<...<<.......>>...>>>>>>>>>]....)
))).<<<<<..<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<
.....>>>>>.....>>>>>......>>>>>.....<<<<<<<....>>>
.>>>>...>>>..>>>.>>...<<<.<<<.................>>>.
>>><<<<<...<<<....>>>.>>>>>......<<<..............
..>>>...............<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of3 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): R17 K20 S23 K24 R25 P27 R28 S29 F30 R31 G32 R33 K34 K39 G40 L44 T45 G47 W48 F50 V51 Q52
• Binding residue (residue number reindexed from 1): R3 K6 S9 K10 R11 P13 R14 S15 F16 R17 G18 R19 K20 K25 G26 L30 T31 G33 W34 F36 V37 Q38

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0006915 apoptotic process
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of3, PDBe:7of3, PDBj:7of3
• PDBsum: 7of3
• PubMed: 34135319
• UniProt: Q8IXM3|RM41_HUMAN Large ribosomal subunit protein mL41 (Gene Name=MRPL41)