Structure of PDB 7dvq Chain 9 Binding Site BS01

Receptor Information
>7dvq Chain 9 (length=409) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKRQHQKDKMYITCAEYTHFYGGKKPDLPQTNFRRLPFDHCSLSLQPFVY
PVCTPDGIVFDLLNIVPWLKKYGTNPSNGEKLDGRSLIKLNFSKNSEGKY
HCPVLFTVFTNNTHIVAVRTTGNVYAYEAVEQLNIKAKNFRDLLTDEPFS
RQDIITLQDPTNQDPSYYLKNTNAETRETLQELYKEFKGDEILAATMAHY
STGKVSASFTSTAMVPETTHEALRYQFVKKKGYVRLHTNKGDLNLELHCD
LTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGK
PFKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFG
RVVGGFDVLTAMENVESDPKTDRPKEEIRIDATTVFVDPYEEADAQIAQE
RKTQLKVAP
Ligand information
>7dvq Chain B (length=90) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccg
uggagaggaacaacccaauuuuuugaggccuugcaaggcu
.<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...
>>>>>>>>>>>...............<<<<<<..>>>>>>
Receptor-Ligand Complex Structure
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PDB7dvq Structure of the activated human minor spliceosome.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		G2 K3 R4 Q5 H6 Q7 K8 Y12 C15 A16
Binding residue
(residue number reindexed from 1)		G1 K2 R3 Q4 H5 Q6 K7 Y11 C14 A15
Enzymatic activity
Catalytic site (original residue number in PDB) R323 F328 Q331 N370 F381 L390 H394
Catalytic site (residue number reindexed from 1) R275 F280 Q283 N322 F333 L342 H346
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0034450 ubiquitin-ubiquitin ligase activity
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0008380 RNA splicing
GO:0016567 protein ubiquitination
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dvq, PDBe:7dvq, PDBj:7dvq
PDBsum7dvq
PubMed33509932
UniProtQ13356|PPIL2_HUMAN RING-type E3 ubiquitin-protein ligase PPIL2 (Gene Name=PPIL2)

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