Structure of PDB 6yws Chain 9 Binding Site BS01

Receptor Information

>6yws Chain 9 (length=206) Species: 367110 (Neurospora crassa OR74A)

QPRPRWSYTPERMKGPGFSLNLVKDPRRKQWMVNSDPAKLDAFYDAFLGQ
GGSRMLSEETKWLAVTHKSFDYGRRGYNTRLAFLGRQIIALETTRSILTS
PVLNEPIVDKYGRTPYNHAALANIDKLIYTQPLDIMDKTKIARMGIDFGL
LTVMRWKPRMPEDLESSGVVVVLNSTLFAIIGAISLEKGAAVAQRIVREK
ILKRLG

Ligand information

>6yws Chain A (length=2820)

guaauggauauaaagcuuauguuuauauauauauauaaguauauaaagag
acuacuaccaauagcuacacuauguauuaaggagaguauaacuuaauuua
uguuuaugauagagguuaucaacauaugaacucuuagagaaauuacuuaa
uaaacgaagugaauugaaauaucuuauuaacuucaggaaaagaaaucaaa
cgagauucuaugauuagugugaacgaaaauagagcagccuauuaaaauaa
guaaaauggcuuuaaagcuguuugaauauuguggggaaccuuccucaaag
gcuaaauauaauacaugaguuacagagaaaaguaccgugagggaaagcuu
ugaaauaguaguuuuauaagcagcucaagcaauaagaaagcgagagcgua
ccuuuugcauaaugggucaccaaguuaauuuuagaugcgagcgaauuaga
ugugcauaguuaaaccgaucauuaaaauaaugaauagugucuaaaguuag
acccgaagccuggugaucuuacuauagucaggacuauaaagguccgaacg
gguuaucguugcaaagauauccgaagaacuaugguaagcgagugaaagac
aacacugacuaggauagcugguuuucugcgaaaccuauaauaguaggcaa
uuuaaguaacaucuuaguagguacagaacuuaaucucagacaagauguag
auuuucauaccuagguaugaaaugcauuuuuuuuuguauacaucggggga
uauuuuaucggugaguauguagacucggaaugacaaagaugaaucuugaa
uaaucagacauagaaugauaagguuguaugucaaaagggaaacagcccag
aacaagaguuaagguuccaaaauuauuauuaagugaaauaaagaaaguuu
uuauauaagucgacaagaagaugggcuuggaagcagccauaauuuaaaga
ucucguaacagagcacuuguuaaaucuuaaaagcaucgaaaauuuaacgg
aucuaaauaauauaccgaaaccuuguccauauguaacauuaguaauaaua
uuaauguuauuugaugggguagcagaacguugagugaaucuuagauuuuu
uuuuuauaacuaaauauagaugauaacucaagugagaauggugacaugag
uaacaaaaaagaguuuaagguaccuaaaagguaucuuagagucucgccua
aagcuuauggcuacgucaaguaacggccucuaaguuuauaaucugaagau
uaugacgaugagaaaacuuugguaccaacauuuaaaagugaaaauugugc
aggaaggauaaaccguaccuagaaucugaaacaaguaagcuaguagagaa
uacgaaggcgugaaugagauaacaaucauaaaggaacucggcaaacuaac
uaccguaacuuagggauaaggagagcucauuagucucgaacgaguaaaaa
ggaagaagcauggaauauuguuguacgacuguuuaauuaaaacaaagcac
uuugcaaaaagacgauaagucuaaguauugagugugauuucugcccgaug
ccggcugguuaacgaauuuucuaaauugaaaaaaaauuugguuucagagg
aacccccgguuaauggcggccgguccuaagguagcgaaaugccuuggccg
uuaaaugcggucuugcaugaaugauguaacgauacaacagcugucucuau
gauugacucagugaaauuggaauaacugugcagauacaguuuaccucuag
uuagacgagaagacccuaugcagcuuuacuguuacuaauuauugaauacg
auucugaaaauuuccaguguaaaagguaaucgauaagauauaauugaaac
accuuuauuuuucuaucguauuauuaaaccuuaaauuaaggaacaauugu
uagaagacaguuuaugcggggcacaggccccauaaagaguaaaugggugu
gucuaaaauguuugcaauuuuuuauaguauauaucaaaucaucuuuaugc
uauucauagaccuuggguacaguauaaaaauuauauauguauuaauuuac
auauauuuuuucuaagaaauuagguaagauuuuguuuauagagaaauuag
auguaaaaaaaaaaucuuaugagggcggauccgcuucuaauauuuuuuug
uaguuauuauuauaauaauaaucauguuuauuacuuaaaaagcuuaaugg
cuuaaucuugccuuacuguuugauuaacaacaaaucuuacagucgcguaa
gcggggcauaggaucacaagauacaaaaaggaaagaucuuggauuuuugg
aaaagcuacgcuagggauaacaggcuaauuugcgcaagaguguacaaaau
gagugcgcgguuuggcaccucggcuugacuaauccucauggaugcagaaa
cuauguaggguacgacuguucgucgauuaaaaaguuacaugagcuggguu
aaauacgucgugagacaguaugguuucuaucuucuagagggaauuagaau
auaauaaggauuaaccuuuguacgaaaggaacaugggguacuauuguuaa
caguuuuauuaaccucugguuuaccuguuguuuaugugccuuagggaugu
uaccgucacuugaguaaauacaauagcauaagcauggcaggaaagcuaag
uuagucaaaaauaagugcugaaagcauauaggcacgaaauuuaccuuaag
auauuucuuaaauauacguaagaaaauauuacguuaauaggcuuaguuug
uaauaaucuagagauuuuaaggaacuaaguacuaauuuuauaaaaaacug
aaugauuaauauaucuuaca

<<<<..<<<<<<.......<<<<<<<<<..>>>>...<<<.......<<<
<<<<<<<......((.....<<<<<<<<<.<<<<<<.....>>.....<<
<<<<................>>>>>>....>>>>..<<....>>......
....<<<<<<.....<<....>>......>>>>>.>.........<<...
.>>..<<<<<<.....<<....>>....>>>>>>..((............
...<<<<<<<<....>>>>>>>>........<<<<<..<<<<>>>>>...
))......>>>>>>>>>.................<<....>>....))..
.....>>>>>>>>>>.......<<<<..<<.........>>..>>>>...
<............>.<<<<<<....<<<<<<<<<<<<<..<<<.......
..>>>...<......>..<<<<<.....>>>>>...>>>>>>>>>>>>>.
.<<.<..<<<<<<<....<<<<<<<<<<..<<<<<....>>.>>>...<<
<..<<<<........>>>>.>>>....>>>>>>>>>>....<<.....>>
.......>>>>>>.>..>.>>..<<<<<<....<<<<<....>>>>>..<
<<<<<<...<<<<<<.<<.....<<<...<..<<<<<<.<<<<<<<<..<
..<<<<<<<<<..>>>>>>>>>>.>>>>.....>>>>.....<<<<.<<<
..>>>..>>>>>>>>.>>..>..>>.>.....>>.>>>>>>...>>>>>>
>.....<<<<<<.<<<......>>>.>>>>>>....<<<......>>>..
.<<<<<.<<...<<<(((.....<<<<<<.....<<......<<..<<<<
<<<........<<<<<<.<....<<<<.......>>>>....>.......
.<<<......>>>..>>>>>>......>>>>>>>.>>...........))
)>>...>>>>>>.>>>...>>>>>>><<<<..<<<<<<<<<<<<....>>
>>>>>>>>>>...>>>>....>>>>>>..<<<<<<..<<<....<<..<<
..<<...>>..>>..>>....>>>.>>>>>>........>>>>>><....
..<<.....<<<.<<<<<<<<<<<.....>>>>>>>>>>>.>>><<<<<.
..<<<<<.<<........((...<<<.<<<...<<<.<<<<<<<..>>>>
>>>>>>...>>>....)).........<<<.<<..(((((..>>.>>>..
............>>>..>>......<<......>>>>>>>..<<<.....
>>>..>>>>>....<<<<....<<<<<<<<.<<................<
<.<<....<<..>>.....>>>>..<<<.<<..<<<<<..>>>>..>.>>
.>.>>.............<<<<<<<<<..<<<.........>>>..<<<<
<<.......<<<<.....>>>>.......>>>>>>....<<.<<<..<<<
<<<<..<<....<.......<<<<<<<.......>>>>>>>.......>.
...>>>>>>>..>>>>><<<..>>>........<...........<<<<<
<.....>>>>>>.....>....>>.....>>.>>>>>>>.....>>.>>>
>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<
..<<<.[[......<<<<.[[<<<<..<<<<<..<<<<<.<<..<<<<<<
<<...<<<<<...........<<<<<<.<<<.....>>>...........
>>>>>>..>>>>>.>>>>>>>>......<<<<.....>>>>....>>.>>
>>>...>>>>>...<<.......>>.<<<<<<...........>>>>.>>
..<<.....<.......<<<..<<<<...>>>>..>>>.>..........
<<<<<<.......>>>>>>.............<<<<<<<<<......>>>
>>>>>>................<<<<<<<.....<<<<.........>>>
>.<<<<..<<<<<<<.<<<.<<.<<<<<..>>>>>>>>>>.>>>.>>>>.
..<<<<<<<<<..>>>>>>>>>........>>>>......<<<...(((>
>>...>>>>>>>...<<<<..<<<.........>>>..>>>>.<<<....
>>>.>>))).......<<<<<<.(...>>>>...)>>>>>>.........
...>>>>..]]>>>>.......<<<<.<...<<<<<...<.........>
...>>>>>....>>>>.>..<<<<.<<<<<...<<<<<<<<.........
>>>>>..>>>..<<<<.....>>>>.......>>>>..>...>>>.>...
..<<<<<<<....>>>.>>>>....]]..>>>.>>>>>>>.....<<<<<
<...<<<<<...<<<<<...............>.>>......<<<<<..>
>>>>>>.<<<<<<...<<<<...<<<<<<<<<<<<<<.<<<..>>>...<
<<<...)))))..>>>>........>>>>>>>>>..>>>>>...>>>>.>
>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>>..
.>>>.>>>....<<<.<<<<<.......>>>>>....<<<<<<<<<<<<.
....<<<<....>>>>....>>>.>>>>>>.>>>.....>>>....>>>>
>>>>.....>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6yws Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.
• Resolution: 2.74 Å
• Binding residue (original residue number in PDB): G75 P76 N81 V83 K84 D85 R88 K89 H127 K128 Y132 R134 K217 R219 M220 S226 S227
• Binding residue (residue number reindexed from 1): G15 P16 N21 V23 K24 D25 R28 K29 H67 K68 Y72 R74 K157 R159 M160 S166 S167

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0004525 ribonuclease III activity

Biological Process

• GO:0006396 RNA processing
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005762 mitochondrial large ribosomal subunit

External links

• PDB: RCSB:6yws, PDBe:6yws, PDBj:6yws
• PDBsum: 6yws
• PubMed: 33056988
• UniProt: Q7S1R6|RM15_NEUCR Large ribosomal subunit protein mL57 (Gene Name=mrpl15)