Structure of PDB 5mrf Chain 9 Binding Site BS01

Receptor Information

>5mrf Chain 9 (length=202) Species: 4932 (Saccharomyces cerevisiae)

VIYLHKGPRINGLRRDPESYLRNPSGVLFTEVNAKECQDKVRSILQLPKY
GINLSNELILQCLTHKSFAHGSKPYNEKLNLLGAQFLKLQTCIHSLKNLQ
FSNLGTKFAKELTSKNTACTFVKLHNLDPFIFWKMRDPIKDGHINGETTI
FASVLNAFIGAILSTNGSEKAAKFIQGSLLDKEDLHSLVNIANENVASAK
AK

Ligand information

>5mrf Chain A (length=2709)

guagaauaauagauuugaaauauuuauuauauagauuuaaagagauaauc
auggaguauaauaauuaaauuuaauuuaauauaacuauuaauagaagguu
acuaauaaauuaauaauuaauuuuaaaaccuaaagguaaaccuuuauauu
aauaauguuaugaauaauuauuaauaauaauaaacuaagugaacugaaac
aucuaaguaacuuaaggauaagaaaucaacagagauauuaugaguauugg
ugagagaaaauaauaaaggucuaauaaguauuaugugaaaaaaauguaag
aaaauaggauaacaaauucuaagacuaaauacuauuaauaaguauaguaa
guaccguaagggaaaguaugaaaaugauuauuuuauaagcaaucaugaau
auauuauauuauauuaaugauguaccuuuuguauaaugggucagcaagua
auuaauauuaguaaaacaauaaguuauaaauaaauagaauaauauauaua
uauaaaaaaauauauauuuaauuaauauuaauugacccgaaagcaaacga
ucuaacuaugauaagauggauaaacgaucgaacagguugauguugcaaua
ucaucugauuaauugugguuaguagugaaagacaaaucugguuugcagau
agcugguuuucuaugaaauauauguaaguauagccuuuauaaauaauaau
uauuauauaauauauuauauaaagaaugguacagcaauuaauauauauua
gggaacuaguuuuuuaauaauauuaaaucucgaaauauuuaauuauauau
aauaaagagucagauuaugugcgauaagguaaauaaucuaaagggaaaca
gcccagauuaagauauaaaguuccuaauaaauaauaagugaaauaaauau
uaaaauaaauauuuaaaaucaaauauauauauauuuguuaauagauaaua
uacggaucuuaauaauaagaauuauuuaauuccuuggaauauuauauuuu
aaaauauaaauacugaauaucuaaauauuauuauuauaauaauaauaaua
ugguaauagaacauuuaaugauaauauauauuaguuauuaauuaauauau
guauuaauuaaauagagaaugcugacaugaguaacgaaaaaaagguauaa
accuuuucaccuaaaacauaagguuuaacuauaaaaguacggccccuaau
uaaauuaaauauaaauauauuuaagaugggauaaucuauauuaauauuua
ucuuaaaauauauaauuauauuauauauuauauauuuauauaauauaaac
uaauaaagaucaggaaaauuaauguauaccguaauguagaccgacucagg
uauguaaguagagaauaugaaggugaauuagauaauuaaagggaaggaac
ucggcaaagauagcucauaaguuagucaauaaagaguaauaagaacaaag
uuguacaacuguuuacuaaaaacaccgcacuuugcagaaacgauaaguuu
aaguauaaggugugaacucugcuccaugcuuaauauauaaauaaaauuau
uuaacgauaauuuaauuaaauuuagguaaauagcagccuuauuaugaggg
uuauaauguagcgaaauuccuuggccuauaauugaggucccgcaugaaug
acguaaugauacaacaacugucuccccuuuaagcuaagugaaauugaaau
cguagugaagaugcuauguaccuucagcaagacggaaagacccuaugcag
cuuuacuguaauuagauagaucgaauuauuguuuauuauauauaaugaua
auucuaaucuuauacuuaauucuuaaguaauauauaauauauauauauau
uauauauuauaagagacaaucucuaauugguaguuuugauggucauuauc
agcaaaaguaucugaauaaguccauaaauaaauauauaaaauuauugaaa
aaaauaauauauauuauauauauuaauuauaaauugaaauauguuuaauu
gaauauauuuuaguaauagauaaaaauauguacaguaaaauuguaaggaa
aacaauaauaacuuucucggaaagaauuaaauuaauauaaugguauaacu
gugcgauaauuguaacacaaacgagugaaacaaguacguaaguauggcau
aaugaacaaauaacacugauuguaaagguuauugauaacgaauaaaaguu
acgcuagggaaggguaauauagcgaaagaguagauauuguaagcuauguu
ugccaccuucgacucaacauuuccucuugguuguaaaagcuaagaagggu
uugacuguucgucaauuaaaauguuacgugaguuggguuaaauacgaugu
gaaucaguaugguuccuaucugcugaaggaaauauuaucaaauuaaaucu
cauuauuaguacgcaaggaccauaaugaaucaacccaugguguaucuauu
gauaauaauauaauauauuuauuaauauauuaucuauauuaguuuauauu
uuaauuauuaucauaguagauaagcuaaguugauaauaaauaaauauuga
auacauauuaaauaugaaguuguuuuaauaagauaauuaaucugauaauu
uuauacuaaaauuaauaauuauagguuuuauauauuauuuauaauuauaa
uauuaauaaaauacuaauuuaucaguuaucuauauaauaucuaaucuauu
auucuauau

<<<<<<<<<<<<<<<.<<......<<<<<<<<<<<<.....<<<<<<<<<
<<...<<<<....<<<<<<<<.>>>>>>>>...<<<<<<<<<<..<<<<.
......<<<<<<<...>>>>>>>....>>>>..<<<....>>>....<<<
<<<<<<..<....>..>>>>>>>>>.........<<<<<<.....<<...
.>>......>>>>>.>..<<.....<<....>>..<<<<<<.....<<..
...>>....>>>>>>...<<<.........<<<<<<.......>>>>>>.
.....<<<<..((((.>>>>..>>>....>>.>>>>>>>>.>>.......
...<<....>>....>>>>....>>>>>>>>>>>.......<<<<<.<<<
<<<......>>>>>>.>>>>>...<.<........>.>.<<<<<<....<
<<<<<<<<<<<<..<<<.....>>>....................<<<<.
<......>.>>>>.......>>>>>>>>>>>>>..<<.<..<<<<<<<..
..<<<<<<<<<<..<<<<......>.>>>...<<<..<<<<........>
>>>.>>>....>>>>>>>>>>...<<.....>>.......>>>>>>...>
..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<..<..<<<<<
<<<<<<<<<<<..>>>>>>>>>..<<<<...<<<...<<<<<<<.<<<<<
<<<<<<<>>>>>>>>>>>>>>>>>>>..>>.>...>>>>>>>>>>>...>
.>>>>>>.>>..<<<<<<.<<<......>>>.>>>>>>....<<<.....
.>>>...<<<.<<<<...<<<(((...<<<<<<<.....<<......<<<
<<<<<<<..>>>>>.....<<<<<<<<..>>>>>>>>.>>>>>.......
...)))>>.............>>>>>>><<<<<..>>>>>.<<<<<<<<.
.>>>>>>>>..>>>...>>>>>>><<<<<<<<<<<<...>>>>>>>>>>>
>....>>>>>>..<<<<<<......<<<<<<<<<<<...>>>>>>>>>>>
......>>>>>>........>>>>>><......<<....<<<<<<.....
.>>>>>><<<<<...<<<<<.<.............((..<<<.<<<...<
<<...<..<<<<..>>>>>..>>>...>>>.....)).<<<<<<<.<<<.
....<<.<<<......>>>.>>.<<<<<<<<<<<..>>>>>>>>>.[[..
>>....>>>........>>>>>>>....>>>...>.....<<......>>
>>>>>..<<<.....>>>..>>>>>..<<<<....<<<<<<<<.<<....
.............<<<....<.....>......>>>.............<
<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>
......>>>>>>>..<<<<.<<<..<<<<<<<<.<<.....<.<<<<<<<
<....>>>>>>>>>.....>>>>>>>>..>>>>><<<<<........>>>
>>........<...........<<<<<.......>>>>>.....>....>
>.>>..>>.>>>>>>......>>.>>>>>>>>.>>>>>>.....>.....
<<<<<........>>>>>..<<<<<<<<.<<<.<<<....<<<<<.<<<<
<<..<<<<.<<<<<<<..<<<.<<<<<<<<<<<.<<.....>>>>>>>>>
>>>>...<<<<<<<<<.<....>.>.>>.<<<<<<<<<<<<<..>>>>>>
>>>>>>>.>>>>>>....>>>>>>>>>>..>>>>..<<<<.>>>><<<<<
<...........>>>.>>>..<<....<<<.....<<<....>>>.....
.....<<<<<<<.....>>>>>>>...>>>.....<<<<<<<<<<<....
>>>>>>>>>>>.................<<<<<<<....<<<<<......
.>>>>><<<..<<<<<<.>>>>>>.>>>......<<.[.(((>>....>>
>>>>>....<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))
].......<<<<<<.<<..))))..>>>>>>>>.............>>>>
..>>>>>>>..<<<<.<.<<<<<....<<.......>>....>>>>>...
>>>>.>..<<<<<..<<<<<..<<<<<<<<<.......>>>>>>>..>>.
<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<..
..>>>.>>>>...>>>..>>>>>>>>>>>.....<<<<<..<<<<<<..<
<<<<<<...............>>>>>>><<<<<<....<<<..<<<<<<<
<<<<<<<<.<<<<<<<<<<....>>>>>>>>>>..<<<<...]].>>>>.
....>>>>>>>>>..>>>>>>..>>>..>>>>>>..<<<.<..<<<<<..
..........>>>>>...>>>>.>>>>>>..>>>>>.....<<<<<<<<<
<.......>>>>>........<<<<<<<<<<..<<...<<<<<..>>>>>
.>>..>>>>>>>.>>>....>>>>>..>>>>>>>>>>>>>>.>>>>>>>>
>>>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5mrf The structure of the yeast mitochondrial ribosome.
• Resolution: 4.97 Å
• Binding residue (original residue number in PDB): R37 N39 G40 L41 R42 R43 Y48 H93 K94 H98 K175 R177 D178 N186 G187 T190
• Binding residue (residue number reindexed from 1): R9 N11 G12 L13 R14 R15 Y20 H65 K66 H70 K134 R136 D137 N145 G146 T149

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0004525 ribonuclease III activity

Biological Process

• GO:0006396 RNA processing
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005762 mitochondrial large ribosomal subunit

External links

• PDB: RCSB:5mrf, PDBe:5mrf, PDBj:5mrf
• PDBsum: 5mrf
• PubMed: 28154081
• UniProt: P36523|RM15_YEAST Large ribosomal subunit protein mL57 (Gene Name=MRPL15)