Structure of PDB 8qrl Chain 8 Binding Site BS01

Receptor Information
>8qrl Chain 8 (length=326) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDR
DPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDL
GCSSMQLDTPERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALA
SILRTYGEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTR
KDLLQRSTHIATKTFQALRIFVNNELNELYTGLKTAQKFLRPGGRLVALS
FHSLEDRIVKRFLLGISMTERFNLSVRQQVMKTSQLGSRAPLMWELIHKK
VLSPQDQDVQDNPRGRSAKLRAAIKL
Ligand information
>8qrl Chain A (length=951) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauagguuugguccuagccuuucuauuagcucuuaguaagauuacacaug
caagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaa
gggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagc
cacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaag
uuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccac
cgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguu
uuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaa
acuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaa
cacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuag
cccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacg
agccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuag
aggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuug
cucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaag
uaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugag
guggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccu
uaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagag
ugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuc
cucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauau
agaggagacaagucguaacaugguaaguguacuggaaagugcacuuggac
g
...((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<
<..<......>......<<.......<<<<.<..<<<.....>>>.>..>
>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>
.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>
>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>
>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<.
.<<<<...............<<<<<<......<<<.<<<.<<<......>
>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>..
.>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>
>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<
<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<
<..<<<<<<<<<<.....<<........>>..........<<<<<<<...
....<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>
>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>
>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<
<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.......
..>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<
<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>
.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>....
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qrl GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Resolution3.34 Å
Binding residue
(original residue number in PDB)		K230 H231 K234 F262 P263 T269 R270 S323 D326 R327 K330 N343 L344 S345 V346 R347 Q349 V350 T353 K381 K400 R402
Binding residue
(residue number reindexed from 1)		K160 H161 K164 F192 P193 T199 R200 S253 D256 R257 K260 N273 L274 S275 V276 R277 Q279 V280 T283 K300 K319 R321
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0070475 rRNA base methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8qrl, PDBe:8qrl, PDBj:8qrl
PDBsum8qrl
PubMed38969660
UniProtA6NJ78|MET15_HUMAN 12S rRNA N4-methylcytidine (m4C) methyltransferase (Gene Name=METTL15)

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