Structure of PDB 8fnc Chain 8 Binding Site BS01

Receptor Information

>8fnc Chain 8 (length=516) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ARPSALHLIFERCKLNLVEFTAQDVYQICTTAYNMDTLGMLQDPDFMRGL
HDAFRRSDQTVISPFQANLIADTFRKVGINSMPKEVSVPEEDAISPESLI
LVLRNMNITKQRDERKINEVLKLMFPILDEFSPTQLSLTVTELARLKSTN
ADFVGKLAKRIMEYNDDLSALDISSAAVSLAYCPGISHNILYRMMQIVEE
RMGEFQPEDYINVLHALNTLGPKFVNTFRKIVECGLQHVENMDAVTLTNY
MVCFSTMDYKQREHIDIYADALVEVATDLSEKDLVMAFIALQRLRLLSDT
MFGTMASCVIRYAAKMDPRNIAPIMDICSTVPHASDHLMKVLMDRAVECT
RILTANQLGDILDILGLYPPAREHPLVQLFGKQARLRLDLMGPDALANAT
RGLANLGYADPEYYAQAAETGFRYGFKDWTLLEPMLMGLSITGQCPPTMV
RVLGSHIAPMARSMSLMEIERANRYLRRLGCEDDFVYKAMASRVLQFVKE
VTPEMPEDLQVLLQRG

Ligand information

>8fnc Chain m (length=17) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

uaauagaauaagauaag

.................

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fnc Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	F83 E160 R163 K300 R337 N338 N374 R441 Y442
Binding residue (residue number reindexed from 1)	F65 E142 R145 K282 R319 N320 N356 R423 Y424

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:8fnc, PDBe:8fnc, PDBj:8fnc
PDBsum	8fnc
PubMed	37410820
UniProt	Q389W4

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