Structure of PDB 7pxa Chain 8 Binding Site BS01

Receptor Information
>7pxa Chain 8 (length=215) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPEQAMRERSELARKGIARAKSVVALAYAGGVLFVAENPSRSLQKISELY
DRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLANVYAQTL
GTIFTEQAKPYEVELCVAEVAHYGETKRPELYRITYDGSIADEPHFVVMG
GTTEPIANALKESYAENASLTDALRIAVAALRALGVASLEVAVLDANRPR
RAFRRITGSALQALL
Ligand information
>7pxa Chain E (length=7) Species: 1773 (Mycobacterium tuberculosis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SNLGQYL
Receptor-Ligand Complex Structure
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PDB7pxa Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		M13 R14 S17 D144 S146 I147
Binding residue
(residue number reindexed from 1)		M6 R7 S10 D137 S139 I140
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0010498 proteasomal protein catabolic process
GO:0019941 modification-dependent protein catabolic process
GO:0030682 symbiont-mediated perturbation of host defenses
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005737 cytoplasm
GO:0005839 proteasome core complex
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0019773 proteasome core complex, alpha-subunit complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pxa, PDBe:7pxa, PDBj:7pxa
PDBsum7pxa
PubMed35022401
UniProtP9WHU1|PSA_MYCTU Proteasome subunit alpha (Gene Name=prcA)

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