Structure of PDB 8q6o Chain 7 Binding Site BS01

Receptor Information
>8q6o Chain 7 (length=275) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DYQAEKEKCKTFLQEFYKKNFKYGVQLANIAHREQVALCIDLDDLAEEDP
ELVDAICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMME
QRYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEV
KPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQ
TRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVGI
TGVFLPMLRLLSETYLESHRLVKMN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8q6o Chain 7 Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8q6o The structural mechanism of dimeric DONSON in replicative helicase activation.
Resolution3.14 Å
Binding residue
(original residue number in PDB)		C183 C205
Binding residue
(residue number reindexed from 1)		C161 C183
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q6o, PDBe:8q6o, PDBj:8q6o
PDBsum8q6o
PubMed37820732
UniProtQ7ZXB1|MCM7B_XENLA DNA replication licensing factor mcm7-B (Gene Name=mcm7-b)

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