Structure of PDB 8i0r Chain 7 Binding Site BS01

Receptor Information

>8i0r Chain 7 (length=105) Species: 9606 (Homo sapiens)

AKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNY
GSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYE
RKKYG

Ligand information

>8i0r Chain G (length=71)

cggccuccgaacgguaagagccuagcauguagaacugaugaugucauacu
uauccugucccuuuuuuuucc

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 8i0r Molecular Basis for the activation of Human spliceosome
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): H4 H5 K25 C61 K95 L98 F99 R102 K103
• Binding residue (residue number reindexed from 1): H3 H4 K24 C60 K94 L97 F98 R101 K102

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000398 mRNA splicing, via spliceosome
• GO:0006397 mRNA processing
• GO:0008380 RNA splicing
• GO:0045893 positive regulation of DNA-templated transcription
• GO:0048863 stem cell differentiation
• GO:1903241 U2-type prespliceosome assembly

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005681 spliceosomal complex
• GO:0005684 U2-type spliceosomal complex
• GO:0005686 U2 snRNP
• GO:0005689 U12-type spliceosomal complex
• GO:0016363 nuclear matrix
• GO:0016607 nuclear speck
• GO:0071005 U2-type precatalytic spliceosome
• GO:0071011 precatalytic spliceosome

External links

• PDB: RCSB:8i0r, PDBe:8i0r, PDBj:8i0r
• PDBsum: 8i0r
• PubMed: 39068178
• UniProt: Q7RTV0|PHF5A_HUMAN PHD finger-like domain-containing protein 5A (Gene Name=PHF5A)