Structure of PDB 7pzy Chain 7 Binding Site BS01

Receptor Information
>7pzy Chain 7 (length=63) Species: 237561 (Candida albicans SC5314) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKIEVDSFSGSKIYPGRGTLFVRGDSKIFRFQSSKSASLFQQRKNPRRIS
WTVLYRRHHKKGI
Ligand information
>7pzy Chain 1 (length=3209) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcg
gaggaauguggcacggcuucugcuguguguuauagccucugacgauacug
ccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaauga
ucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugc
gaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugg
gggcccauuagggugcaccaucgaccgauccugauguguucggauggauu
ugaguaagagcauagcuguugggacccgaaagauggugaacuaugccuga
auagggugaagccagaggaaacucugguggaggcucguagcgguucugac
gugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaac
caucuaguagcugguuccugccgaaguuucccucaggauagcagaagcuc
guaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaa
ugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcu
uaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugg
uaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccg
gaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagc
cggacgguggccauggaagucggaauccgcuaaggaguguguaacaacuc
accggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuac
uuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcg
uggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucu
agugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaaga
cugaaguggggaaagguuccaugucaacagcaguuggacauggguuaguc
gauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggc
caaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauu
cuucacggcaacguaacugaauguggagacgucggcgugagcccugggag
gaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccg
gagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggu
gcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugcc
aagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguu
gauagaauaauguagauaagggaagucggcaaaauagauccguaacuucg
ggauaaggauuggcucuaaggaucgggugucuugggccuuguguagacgc
gaggucuuuauggccguccggggcacguuuaacgaucaacuuagaacugg
uacggacaaggggaaucugacugucuaauuaaaacauagcauugugaugg
ucagaaagugauguugacacaaugugauuucugcccagugcucugaaugu
caaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaug
acucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaug
aauggauuaacgagauucccacugucccuaucuacuaucuagcgaaacca
cagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguu
gagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaa
gcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcga
uccggguugaagacauugucagguggggaguuuggcuggggcggcacauc
uguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaa
ucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagug
ugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaa
uuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuugug
gcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcu
cuuccuaucauaccgaagcagaauucgguaagcguuggauuguucaccca
cuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuu
uacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagag
gaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacg
ccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaa
uccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacg
aauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuu
agcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgc
ggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaag
caguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugu
cugauuugu
.......................<<<<<<.....<......>......>>
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....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>
>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<......<.
....>......>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<
<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>
>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>
>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<
..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<
..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>
>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<
<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<.
.......>>>>>>>>....>>>>>>>>>...<<.......>>......>>
>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<
...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<....
.>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<.
.....>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.
....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.
....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<
<<<.<<....<<.........>>....>>.........<<......>>..
.>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>
>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..
<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>
>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<
<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<
<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>
......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.
....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<
<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>
....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.
..>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>
>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>
..<<<<.....<<<<<<<.<<.........<.....<<<<<.........
......>>>>><<.<<<<<<<<<<<..<<<<<.<<.....<<<.<<<..<
..>.>>>.>>>......>>>>>.>>.......>>>>>..>>>>>>.>>..
..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<
<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<
.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......
>>>>>>........<...........<<<<<.......>>>>>.....>.
....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>.
...<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{
{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<....
.<<<<..<<<<<......>>>>>..............<<<<...>>>>..
>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<
<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......
>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<......
.>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>
>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<
<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.
<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>
.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}
}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<............
.....>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>
>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...
>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<.....
.....<<<<....>>>>......>>.......<<<<<<...<<<<<<<..
<<<......>>>..>>>>>>>.>>>>>>................>>>.>>
>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<
<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>
..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pzy E-site drug specificity of the human pathogen Candida albicans ribosome.
Resolution2.32 Å
Binding residue
(original residue number in PDB)
G16 R17 G18 S34 K35 S38 Q42 K44 R48 I49 S50 W51 R56 K61
Binding residue
(residue number reindexed from 1)
G16 R17 G18 S34 K35 S38 Q42 K44 R48 I49 S50 W51 R56 K61
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7pzy, PDBe:7pzy, PDBj:7pzy
PDBsum7pzy
PubMed35613268
UniProtQ5A6A1|RL24A_CANAL Large ribosomal subunit protein eL24 (Gene Name=RPL24A)

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