Structure of PDB 6xtx Chain 7 Binding Site BS01

Receptor Information
>6xtx Chain 7 (length=598) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDD
VAEDDPELVDSICENARRYAKLFADAVQELLPQYKQYPAELMRRFELYFQ
GPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGA
ETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQE
HSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRGLLSETY
LEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGH
EDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRL
APRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEF
DKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNP
RRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQP
PSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKD
ATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xtx CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes.
Resolution3.29 Å
Binding residue
(original residue number in PDB)		S410 V412 V418 R420 A472
Binding residue
(residue number reindexed from 1)		S363 V365 V371 R373 A425
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 DNA damage response
GO:0008283 cell population proliferation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:0042325 regulation of phosphorylation
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016020 membrane
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xtx, PDBe:6xtx, PDBj:6xtx
PDBsum6xtx
PubMed32453425
UniProtP33993|MCM7_HUMAN DNA replication licensing factor MCM7 (Gene Name=MCM7)

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