Structure of PDB 6w6l Chain 7 Binding Site BS01

Receptor Information
>6w6l Chain 7 (length=290) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KNKNSRLAQAWFNTHRELLESNFTLVGDDGTNKEATSTGKLNQENEHIYN
LWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMRPVSDQVQIKVTMNDEDM
DTYVFAVGTRKALVRLQKEMQDLSEFKYGLPDSLAILSEMGEVTDGMMDT
KMVHFLTHYADKIESVHFSDQKRTLLFTFNVPGSGNTYPKDMEALLPLMN
MVIYSIDKAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRRE
EKKRAEKERIMNEEDPEKQRRLEEAALRREQKKLEKKQMK
Ligand information
>6w6l Chain t (length=3510) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggggcgcgggacaugug
gcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccu
ucugaucgaggcccagcccguggacggugugaggccgguagcggcccccg
gcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaa
agcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauag
ucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguuc
aagagggcgugaaaccguuaagagguaaacgggugggguccgcgcagucc
gcccggaggauucaacccggcggcggguccggccgugucggcggcccggc
ggaucuuucccgggcgggggaccgucccccggaccggcgaccggccgccg
ccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcuggg
aaggcccggcggggaagguggcucggggcccccgaguguuacagcccccc
cggcagcagcacucgccgaaucccggggccgagggagagacccgucgccg
cgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcu
cucccagggggcggggcggacuguccccagugcgccccgggcgggucgcg
ccgucgggcccggggggccacgcgcgcgucccccgaagggggggacggcg
gagagcgcacggggucggcggcgacgucggcuacccacccgacccgucuu
gaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacg
aaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccga
ggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgu
cucgcccgccgcgccggggagguggagcacgagcgcacguguuaggaccc
gaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugg
uggagguccguagcgguccugacgugcaaaucggucguccgaccugggua
uaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaagu
uucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaag
cgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaac
uuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaug
cgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaug
aaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccag
aaaagguguugguugauauagacugccgaaucaacuagcccugaaaaugg
auggcgcuggagcgucgggcccauacccggccgucgccggcgucgagagu
ggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgagua
ggagggccgcugcggugagccuugaagccuagggcgcgggcccgggugga
gccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaa
cuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacau
gggucagucgguccugagagaugggcgagcgccguuccgaagggacgggc
gauggccuccguugcccucggccgaucgaaagggagucggguucagaucc
ccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaa
cgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuu
ucuuugugaagggcagggcgcccuggaauggguucgccccgagagagggg
cccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucg
cuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccgu
acccauauccgcagcaggucuccaaggugaacagccucuggcauguugga
acaauguagguaagggaagucggcaagccggauccguaacuucgggauaa
ggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggg
gaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcgggu
guugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaa
auucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagg
uagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacg
agauucccacugucccuaccuacuauccagcgaaaccacagccaagggaa
cgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucu
agucuggcacggugaagagacguuuuuucacugacccggugaggcggggg
ggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgg
gcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgg
uacaccugucaaacgguaacgcagguguccuaaggcgagcucagggagga
cagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuu
ucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccu
uuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacugg
cuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaug
ucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguu
cacccacuaauagggaacgugagcuggguuuagaccgucgugagacaggu
uaguuuuacccuacugaugauguguuguugccaugguaauccugcucagu
acgagaggaaccgcagguucagacauuugguguaugugcuuggcugagga
gccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaa
gucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgg
uuggccucggauagccgguccccgccggggguccggugcggagugcccuu
cguccugggaaaccucgcccgucacgcaccgcacguucguggggaaccug
gcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacgu
agcagagcagcucccucgcugcgaucuauugaaagucagcccucgacaca
aggguuuguc
.........................<<<<<<.....<<....>>......
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.......>.>..................................>>>>..
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...(((((..<<<<<<)))))..]]]........................
..........<<....>>...............<<<......>>>.....
.............................<<<<<<<<..<<<........
..<<.<.<<<<....<<.<..<..<.........<....<<.......<<
<<.<<<..<<<<..>>>>>>>>>>>..>>....>..........>..>..
>.>>....>>>>.>.>>.....<<<<<<<<.<<<<<<<<<<.<<<.....
...<<<.<<.<<<.......<<<<<<<<.>>>>>>>>........>>>.>
>>>>...........>>>...>>>>>>>>>>...................
......<<<<<<..>>>>>>....<<.......<<...<....<.<<<<<
...<<...>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>....
>....>>.........>>..........<<<<<<....>>>>>>......
..............>>>.>>>>>....>>>...>>>>>>>>..<<<<...
.....>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<......
..>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..
<<<<<..<<<...<.....[[.......>...>>>...>>>>>.<<<<<<
<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.
<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>
>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>
>...<<.......>>......>>>>>>......>.>>..<<<<<<....<
.<<<....>>>.><<.<<<<<<<........<<<.<<<<<<<<<...<<<
....<<...<.<<<<..<.<<<.........>>>.>>>>>.>...>>..>
.>>...>>>>>>>....<<<<<<<<.........>>>>>>>>....>>>>
>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<....
..>>>...<<<<<<<...<<<(((.......<<<<<.....<<.......
...<<<.<<<<<<<<<<............>>>>>>>>>>>>>........
..))).>>...>>>>>..>>>...>>>>>>><<<<<<.<...........
.....]].....<.....>...................>.>>>>>>....
>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...
>>>>>>>>>>........>>>>>><<<....<<.....<<<<<<......
.>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>
>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<
<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>
>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....
>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>
>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>
>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>
>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>.
.>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<
.....<<<<<<<.<<.........<.....<<<<<...............
>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<
<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>
......>>>>>>>...<<..<<<..<<<<<<....<<<...<.<<<<...
.>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>......
..<...........<<<<<.......>>>>>.....>.....>>....>>
.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<....
....>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<
.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..
.<.<<...........>>>...............<<<<<<<......>>>
>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>
>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.
......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<
.......>>>>..>>><<<<....>>>>>>))).......((((((..((
(..>>>>>>.)))))))))..........]]]]..}}]]]].......<<
.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......
<<<<<.<<<<<<..<.<.<<<<<......>>>>>.>...>.<<<......
...>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>
>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.....
............>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>
>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>
>>>>...>>>>>.>>>...>.>>>>>>......<<<<<<.<<..<<<..<
..<.............<.<<<<....>>>>.>.............>....
<<<..<<<<........>>>>..>>>..........>...>>>...>>>>
>>>>.<<<<<.<.............>.....<.<<<<<<<.<<.....<<
<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>.
..>>>>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w6l An ER translocon for multi-pass membrane protein biogenesis.
Resolution3.84 Å
Binding residue
(original residue number in PDB)
K395 R400 K419 H422 Q430 R433 R455 R462 R463 K467 K470
Binding residue
(residue number reindexed from 1)
K211 R216 K235 H238 Q246 R249 R271 R278 R279 K283 K286
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0032469 endoplasmic reticulum calcium ion homeostasis
Cellular Component
GO:0005783 endoplasmic reticulum

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6w6l, PDBe:6w6l, PDBj:6w6l
PDBsum6w6l
PubMed32820719
UniProtQ96A33|CCD47_HUMAN PAT complex subunit CCDC47 (Gene Name=CCDC47)

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