Structure of PDB 8h6e Chain 6g Binding Site BS01

Receptor Information
>8h6e Chain 6g (length=61) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHEEQVVLGLYIV
RGDNVAVIGEI
Ligand information
>8h6e Chain 6A (length=59) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acgauacagagaagauuagcauggccccugcgcaaggaugacauucguga
agcguauuu
..................................................
.........
Receptor-Ligand Complex Structure
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PDB8h6e Structural Insights into Human Exon-defined Spliceosome Prior to Activation
Resolution3.2 Å
Binding residue
(original residue number in PDB)		Q32 T33
Binding residue
(residue number reindexed from 1)		Q29 T30
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005688 U6 snRNP
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome
GO:0120115 Lsm2-8 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h6e, PDBe:8h6e, PDBj:8h6e
PDBsum8h6e
PubMed38658629
UniProtO95777|LSM8_HUMAN U6 snRNA-associated Sm-like protein LSm8 (Gene Name=LSM8)

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