Structure of PDB 8qu5 Chain 6 Binding Site BS01

Receptor Information

>8qu5 Chain 6 (length=324) Species: 9606 (Homo sapiens)

RRTPPLGPMPNSDIDLSNLERLEKYRSFDRYRRRAEQEAQAPHWWRTYRE
YFGRTQQLLERKQAIQELRANVEEERAARLRTASVPLDAVRAEWERTCGP
YHKQRLAEYYGLYRDLFHGATFVPRVPLHVAYAVGEDDLMPVYCGNEVTP
TEAAQAPEVTYEAELWTLLLTSLDGHLLEPDAEYLHWLLTNIPGNRVAEG
QVTCPYLPPFPARGSGIHRLAFLLFKQDQPIDFSYQLAQRTFRTFDFYKK
HQETMTPAGLSFFQCRWDDSVTYIFHQLLDMREPVFEFVRPPPYHPKQKR
FPHRQPLRYLDRYRDSHEPTYGIY

Ligand information

>8qu5 Chain A (length=1049)

gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcgccuggugauagcugguugucc
aagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaaucccc
uuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuagg
aaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaa
aagcagccaccaauuaagaaagcguucaagcucaacaccucccaaacaua
uaacugaacuccucacacccaauuggaccaaucuaucacccuauagaaga
acuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccug
cgucagaucacugacaauuaacagcccaauaucuacaaucaaccaacaag
ucauuauuacccucacugucaacccaacaggcaugcucauaaggaaaggu
uaaaaaaaguaaaaggaaacaucaccucuagcaucaccaguauuagaggc
cagcugucucuuacuuuuaaccagugaaauugaccugcccgugaggcggg
cauaacacagcaagacgagacccuauggagcuuuaauuuauuaaugcaaa
caccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaacc
uccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauuga
uccaauaacuugaccaacggaacaaguuacccuaggguaucuacuuuauu
ccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgcc
uucuaaaugauaucaucucaacuuaauacccacacccaagaacaggguu

<<<.......<<<<..................................<.
.....>...........<<.....>>.......>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<....>.>>>>......>.>>..<<<<
<<....<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>...
..>>>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>...<<<
......>>>....<<<.<<<...<..............<....<<<....
.....>>>....>.......<<<......>>>..................
....>...>>>>>>........>>>>>>...<<<<<......>>>>>...
......>>>>>><......<<..<<<....>>><<<<..<<<<.......
.<<<<<....>>>>>......<<<...<<<<...................
....>>>>.......>>>.....<<....>>.>>>>.....>>>>..<<<
<...<<<<<<<<.<<.........<<<<<<.............>>>>>>.
.......>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>
>.......<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<..
....>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>
>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.......
..<<<....>>>............>>>>..>>>>>>>..>>>.>>..<<<
.<<<.................>>>.>>><<<<<...<<<....>>>.>>>
>>.<<<.<............>.>>>........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8qu5 GTPBP8 plays a role in mitoribosome formation in human mitochondria.
• Resolution: 2.42 Å
• Binding residue (original residue number in PDB): R27 R28 R72 H351 P352 R356 H359 R360 R364 R368 T376 G378 I379 Y380
• Binding residue (residue number reindexed from 1): R1 R2 R46 H295 P296 R300 H303 R304 R308 R312 T320 G322 I323 Y324

Gene Ontology

Molecular Function

• GO:0005515 protein binding

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8qu5, PDBe:8qu5, PDBj:8qu5
• PDBsum: 8qu5
• PubMed: 38969660
• UniProt: Q96DV4|RM38_HUMAN Large ribosomal subunit protein mL38 (Gene Name=MRPL38)