Structure of PDB 8fni Chain 6 Binding Site BS01

Receptor Information
>8fni Chain 6 (length=453) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHLSARNIATEALQMKKLHQERGGNPMLAQQARRVLFATSIAGQNLDARS
VALLLNTAVYFGMESDAKLVRECIDYCLKNDKLITVDVLPIVVTACATLK
SRDAREVIEMQAQKAARNAKFLDAKDVTNIISAFSKTGINHEKLFAFLSR
RVQTLARVGEFEAAHLVILANAFSRLRYRDKFLFGAIARRAMSLRERVTV
NELVPLIVAFSKIGLKDPKLSKRFATKAMEYVDQMNAEQVASMFMAFAYF
GIRYDQLFGVLTNRAVELIDEFNAQYISTTLNAFQRIGINNPELFDNLAE
RALAVVQDHDARDISKTVTALAHFGLKDEELFKRLASHAASIADQFDAMG
LVNTAHAFARTNFLQQDMAVALSERSVYVCRLLDAGETRRLLWALAKFQV
RDPKILTPVFNRCLALHYDFFADPTGSEEIEEIFDFYGPNFCPPLYQLYI
SRG
Ligand information
>8fni Chain m (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uauauaauagaauaagauaag
.....................
Receptor-Ligand Complex Structure
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PDB8fni Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R64 K75 E79 R107 K183 K194 H223 I226 N229 R233 R235 N259 E260 K270 Y307 R370 M407
Binding residue
(residue number reindexed from 1)		R6 K17 E21 R49 K125 K136 H165 I168 N171 R175 R177 N201 E202 K212 Y249 R312 M349
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
Biological Process
GO:0000963 mitochondrial RNA processing
GO:0006396 RNA processing
GO:0044528 regulation of mitochondrial mRNA stability
GO:0090615 mitochondrial mRNA processing
GO:1900864 mitochondrial RNA modification
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0031019 mitochondrial mRNA editing complex
GO:0035770 ribonucleoprotein granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fni, PDBe:8fni, PDBj:8fni
PDBsum8fni
PubMed37410820
UniProtQ57ZX7

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