Structure of PDB 8fnf Chain 6 Binding Site BS01

Receptor Information
>8fnf Chain 6 (length=452) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSHLSARNIATEALQMKKLHQERGGNPMLAQQARRVLFATSIAGQNLDAR
SVALLLNTAVYFGMESDAKLVRECIDYCLKNDKLITVDVLPIVVTACATL
KSRDAREVIEMQAQKAARNAKFLDAKDVTNIISAFSKTGINHEKLFAFLS
RRVQTLARVGEFEAAHLVILANAFSRLRYRDKFLFGAIARRAMSLRERVT
VNELVPLIVAFSKIGLKDPKLSKRFATKAMEYVDQMNAEQVASMFMAFAY
FGIRYDQLFGVLTNRAVELIDEFNAQYISTTLNAFQRIGINNPELFDNLA
ERALAVVQDHDARDISKTVTALAHFGLKDEELFKRLASHAASIADQFDAM
GLVNTAHAFARTNFLQQDMAVALSERSVYVCRLLDAGETRRLLWALAKFQ
VRDPKILTPVFNRCLALHYDFFADPTGSEEIEEIFDFYGPNFCPPLYQLY
IS
Ligand information
>8fnf Chain m (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB8fnf Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		R64 K75 R107 K183 K194 H223 R233 K270 K274 E296 Y307 R370 M407
Binding residue
(residue number reindexed from 1)		R7 K18 R50 K126 K137 H166 R176 K213 K217 E239 Y250 R313 M350
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
Biological Process
GO:0000963 mitochondrial RNA processing
GO:0006396 RNA processing
GO:0044528 regulation of mitochondrial mRNA stability
GO:0090615 mitochondrial mRNA processing
GO:1900864 mitochondrial RNA modification
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0031019 mitochondrial mRNA editing complex
GO:0035770 ribonucleoprotein granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fnf, PDBe:8fnf, PDBj:8fnf
PDBsum8fnf
PubMed37410820
UniProtQ57ZX7

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