Structure of PDB 8fnc Chain 6 Binding Site BS01

Receptor Information

>8fnc Chain 6 (length=452) Species: 5691 (Trypanosoma brucei)

VSHLSARNIATEALQMKKLHQERGGNPMLAQQARRVLFATSIAGQNLDAR
SVALLLNTAVYFGMESDAKLVRECIDYCLKNDKLITVDVLPIVVTACATL
KSRDAREVIEMQAQKAARNAKFLDAKDVTNIISAFSKTGINHEKLFAFLS
RRVQTLARVGEFEAAHLVILANAFSRLRYRDKFLFGAIARRAMSLRERVT
VNELVPLIVAFSKIGLKDPKLSKRFATKAMEYVDQMNAEQVASMFMAFAY
FGIRYDQLFGVLTNRAVELIDEFNAQYISTTLNAFQRIGINNPELFDNLA
ERALAVVQDHDARDISKTVTALAHFGLKDEELFKRLASHAASIADQFDAM
GLVNTAHAFARTNFLQQDMAVALSERSVYVCRLLDAGETRRLLWALAKFQ
VRDPKILTPVFNRCLALHYDFFADPTGSEEIEEIFDFYGPNFCPPLYQLY
IS

Ligand information

>8fnc Chain m (length=17)

uaauagaauaagauaag

.................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fnc Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): R64 K75 E79 R107 K183 K194 H223 I226 N229 R233 R235 K270 E296 Y307 R344 R370
• Binding residue (residue number reindexed from 1): R7 K18 E22 R50 K126 K137 H166 I169 N172 R176 R178 K213 E239 Y250 R287 R313

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003729 mRNA binding

Biological Process

• GO:0000963 mitochondrial RNA processing
• GO:0006396 RNA processing
• GO:0044528 regulation of mitochondrial mRNA stability
• GO:0090615 mitochondrial mRNA processing
• GO:1900864 mitochondrial RNA modification

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0031019 mitochondrial mRNA editing complex
• GO:0035770 ribonucleoprotein granule

External links

• PDB: RCSB:8fnc, PDBe:8fnc, PDBj:8fnc
• PDBsum: 8fnc
• PubMed: 37410820
• UniProt: Q57ZX7