Structure of PDB 8d8j Chain 6 Binding Site BS01

Receptor Information

>8d8j Chain 6 (length=250) Species: 4932 (Saccharomyces cerevisiae)

FSRRRIAYPFYPFKKLGRQHPKKHDTNLKTAMRQFLGPKNYKGEYVMNKY
FTVPTNHVPNYIKPDLERGQSLEHPVTKKPLQLRYDGTLGPPPVENKRLQ
NIFKDRLLQPFPSNPHCKTNYVLSPQLKQSIFEEITVEGLSAQQVSQKYG
LKIPRVEAIVKLVSVENSWNRRNRVSSDLKTMDETLYRMFPVFDSNTKVI
YGELVEGERSQYKFTNAKVGKVGYRYGSGNRDNKKDRRIGFNKLGQMVYI

Ligand information

>8d8j Chain a (length=1183)

uuuuauauauauauaauaaggaaaaguauuuauaagaauaugauguuggu
ucagauuaagcgcuaaauaaggacaugacacaugcgaaucauacguuuau
uauugagauaauaaauaugugguguaaacgugaguaauuuuauuaggaau
uaaugaacuauagaauaagcuaaauacuuaauauuauauaaaaauaauuu
auauaauaaaaaggauauauauauauauauuuaucuauagucaagccaau
aaugguuuagguaguagguuuauuaagaguuaaaccuagccaacgaucca
uaaucgauaaugaaaguuagaacgaucacguugacucugaaauauaguca
auaucuauaagauacagcagugaggaauauuggacaaugaucgaaagauu
gauccaguuacuuauuaggaugauauauauauauauauaaauugauuaaa
aauaaaauccauaaauaauuaaaauaaugauauuaauuaccauauauuua
uauggauauauauauauuuuaauaguccugacuaauauuugugccagcag
ucgcgguaacacaaagagggcgagcguuaaucauaaugguuuaaaggauc
cguagaaugaauuauauauaauuuagaguuaauaaaauauaauuaaagaa
uuauaauaaauuauaagacuaauauaugugaaaauauuaauuaaauauua
acugacauugagggauuaaaacuagagucuaguaguaugaauacaauuau
uuauaauauauauauaaauaauaaaugaaaaugaaaguauuccaccugaa
gaguacguuagcaauaaugaaacucaaaacaauagacgguuacagacuua
agcaguggagcauguuauuuaauucuaccauauuuugaauauuauaauaa
uuauaauuauuauauuacaggcguuacauuguuaaugauccuuauaauau
ggguaauagacgugcuauaauaaaaugauaaaaaacauuuuaaauaugaa
aaaagaauugcuaguaauacguaaauuaguauguuacggugaauauucua
acuguuucgcacuaaucacucaucacgcguugaaacauauuauuaucuua
uuauuuauauaauauuuuuuaauaaauauuauuaauuuauauuuauuuau
aucagaaauaauaugaauuaaugcgaaguugaa

..<<<<<<..>>>>>>...................<<<<..[.((((.>>
>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<<<<<<<
<<<<..>>>>>>>>>>..>>>>>.....<<<........<<<<<.<<...
...<..<<<<<<<<.<<<<.......>>>>...<<<<<<<<<.....>>>
>>>>>>......<<<<<<<<<..>>>>>>>>>.>>>>>>>>.>..>>>>>
>><<<....<<<..<<<<<<<<........>>>>>>>>>>>......>>>
..<<<<.<<<<....>>>>...>>>>.>>><<<<<<.........>>>>>
><<<<.....>>>>..>>>>>>.........<<<....<<<<....>>>>
..>>>...>.>>>>>>.<<<<..<<<<<<....>>>>>>..<<......>
>.....>>>>..<<<<<<<................>>>><<<<<<<..>>
>>>>>.<<<<..>>>>.>>>....<<<<<(((.....<<<<.....<<.)
))>>.......>>>>.>>>>>..>>>>>>>>>.....<<<((.....<<<
<...<.<<.<<<<<<..>>>>>>...<<<<<<<<.....<<<<<<<<<..
<<<<<<<..>>>>>>>..>>.......<<....>>.>>>>>>>..>>>>>
>>>...>>>...>>>>....<<<<<<.>>>>>>.....<<<<<<.<<<<<
<<<<<<<..>>.>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<<.
......<<<<....>>>>.....>>..)))).]<<.<<...<<<<.....
.<<<<<..<<<<<<<<<<.........<<<<<<<.....<<.<<<<<<<<
<<..>>>>>>>>>>.>>.<<<.<<..<<<<...>>>>>>>>>...>>>>>
>>...>>.>>>>>>>>.....<<<<<<........>>>>>>.....<...
>.....>>>>>.....<<.<<<<<.........>>>>>>>..........
.>>>>..>>..>>......<<<.<.<<<<<<<<..<<<<<<<<<.<<<..
.<<<..<<<.<<<<<...<<<<<<<...>>>>>>>...>>>>>>>>..>>
>..>>>>>>>>>>>>..>>>>>>>>..>.>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8d8j Principles of mitoribosomal small subunit assembly in eukaryotes.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): S28 R29 R30 Y34 F39 K41 L42 R44 Q45 H46 P47 K48 K49 H50 T52 N53 K55 K65 N66 Y67 M73 H100 P101 L115 R198 R200 R304 G322 G324 N325 R326 D327 N328 K329 K330 R332 Y344
• Binding residue (residue number reindexed from 1): S2 R3 R4 Y8 F13 K15 L16 R18 Q19 H20 P21 K22 K23 H24 T26 N27 K29 K39 N40 Y41 M47 H74 P75 L89 R172 R174 R209 G227 G229 N230 R231 D232 N233 K234 K235 R237 Y249

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8d8j, PDBe:8d8j, PDBj:8d8j
• PDBsum: 8d8j
• PubMed: 36482135
• UniProt: P53292|RT35_YEAST Small ribosomal subunit protein mS45 (Gene Name=MRPS35)