Structure of PDB 7enc Chain 6 Binding Site BS01

Receptor Information
>7enc Chain 6 (length=606) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEP
VCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFI
KLCTVSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLRNSEEET
QTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTAV
LRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLG
NSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGH
TTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLG
LTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMS
PEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNV
FALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSF
DLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQ
DTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQK
VLAATD
Ligand information
>7enc Chain X (length=69) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagggcgcctataaaagggggtgggggcgcgttcgtcctcagtcgcgatc
gaacactcgagccgagcag
Receptor-Ligand Complex Structure
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PDB7enc Structures of the human Mediator and Mediator-bound preinitiation complex.
Resolution4.13 Å
Binding residue
(original residue number in PDB)		K449 K526
Binding residue
(residue number reindexed from 1)		K334 K411
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0001666 response to hypoxia
GO:0006265 DNA topological change
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0006368 transcription elongation by RNA polymerase II
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0008104 protein localization
GO:0009411 response to UV
GO:0009650 UV protection
GO:0035315 hair cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0048568 embryonic organ development
GO:1901990 regulation of mitotic cell cycle phase transition
Cellular Component
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7enc, PDBe:7enc, PDBj:7enc
PDBsum7enc
PubMed33958484
UniProtP19447|ERCC3_HUMAN General transcription and DNA repair factor IIH helicase/translocase subunit XPB (Gene Name=ERCC3)

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