Structure of PDB 6zm5 Chain 6 Binding Site BS01

Receptor Information

>6zm5 Chain 6 (length=354) Species: 9606 (Homo sapiens)

RRTPPLGPMPNSDIDLSNLERLEKYRSFDRYRRRAEQEAQAPHWWRTYRE
YFGEKTDPKEKIDIGLPPPKVSRTQQLLERKQAIQELRANVEEERAARLR
TASVPLDAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPRVPLHVA
YAVGEDDLMPVYCGNEVTPTEAAQAPEVTYEAEEGSLWTLLLTSLDGHLL
EPDAEYLHWLLTNIPGNRVAEGQVTCPYLPPFPARGSGIHRLAFLLFKQD
QPIDFSEDARPSPCYQLAQRTFRTFDFYKKHQETMTPAGLSFFQCRWDDS
VTYIFHQLLDMREPVFEFVRPPPYHPKQKRFPHRQPLRYLDRYRDSHEPT
YGIY

Ligand information

>6zm5 Chain A (length=1534)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuc
uaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuug
gacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauag
uaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccca
cuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauugga
ccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaa
acauucuccuccgcauaagccugcgucagauuaaaacacugaacugacaa
uuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacu
gucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaag
gaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagc
aucaccaguauuagaggcaccgccugcccagugacacauguuuaacggcc
gcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauag
ggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaac
cagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacga
gaagacccuauggagcuuuaauuuauuaaugcaaacaguaccaaaccugc
auuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagc
aguacaugcuaagacuucaccagucaaagcgaacuacuauacucaauuga
uccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaau
ccuauucuagaguccauaucaacaauaggguuuacgaccucgauguugga
ucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacg
auuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguu
ucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaagg
ccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagu
auuauacccacacccacccaagaacaggguuugu

<<<.......<<<<....................................
.<......>.........<.....<<.....>>....>........>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
....>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>
>>>.<.<<<......>>>.>..<<<.<<<...<..............<..
..<<<.........>>>....>.......<<<......>>>.........
...........................>...>>>>>>........>>>>>
>...<<<<<......>>>>>.........>>>>>><......<<..<<<.
...>>><<<...<<<<........<<<<<.<<........>>.>>>>>..
....<<<...<<<<.......................>>>>.......>>
>.....<<......>>.>>>>......>>>..<<<<...<<<<<<<<.<<
.........<......<<<<<<..<<<.........>>>...<<<<<<..
...........>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><
<<<<<......>>>>>>........<...........<<<<<<.....>>
>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>
>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<
......<<<<.<<<<<<..<<<<<.<<<<<<<<....<..>......>>>
>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..
<<.....<<<..<<<<.....>>>>..>>>...........>>.......
..<<<....>>>............>>>>..>>>>>>.......<<<..<.
<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<
.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>
>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....
>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<
<...<<<....>>>.>>>>>......<<<................>>>..
....>..........<<<<.......>>>>....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zm5 Mechanism of membrane-tethered mitochondrial protein synthesis.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): R27 R28 R72 Y350 H351 P352 R356 H359 R360 R364 R368 T376 G378 I379 Y380
• Binding residue (residue number reindexed from 1): R1 R2 R46 Y324 H325 P326 R330 H333 R334 R338 R342 T350 G352 I353 Y354

Gene Ontology

Molecular Function

• GO:0005515 protein binding

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zm5, PDBe:6zm5, PDBj:6zm5
• PDBsum: 6zm5
• PubMed: 33602856
• UniProt: Q96DV4|RM38_HUMAN Large ribosomal subunit protein mL38 (Gene Name=MRPL38)