Structure of PDB 6raz Chain 6 Binding Site BS01

Receptor Information
>6raz Chain 6 (length=588) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKDEVGIRAQKLFQDFLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDV
EKYDQNLATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVP
TRKVRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVE
QQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGC
IPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDYRMAFLACSVQATDLP
MSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKR
GILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRA
IYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMD
QRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSL
QQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERA
YTREEVLRYVTFARQFKPVISQEAGHMLVENYGHLRQRDTGTSWRITVRQ
LESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIR
Ligand information
Receptor-Ligand Complex Structure
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PDB6raz Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Resolution4.46 Å
Binding residue
(original residue number in PDB)		A424 V425 R478
Binding residue
(residue number reindexed from 1)		A366 V367 R420
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
GO:1990518 single-stranded 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0007307 eggshell chorion gene amplification
GO:0032508 DNA duplex unwinding
GO:0051301 cell division
GO:1902969 mitotic DNA replication
Cellular Component
GO:0005634 nucleus
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6raz, PDBe:6raz, PDBj:6raz
PDBsum6raz
PubMed31484077
UniProtQ9V461|MCM6_DROME DNA replication licensing factor Mcm6 (Gene Name=Mcm6)

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