Structure of PDB 6qw6 Chain 5X Binding Site BS01

Receptor Information
>6qw6 Chain 5X (length=583) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKDKS
KELHAIKERYLRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGID
LKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWS
QKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDK
CGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPK
IDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISR
EDQGFRLRMGEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGF
EPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATM
PPAVERLARSYLRRPAVVYIGAGKPHERVEQKVFLMSESEKRKKLLAILE
QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLREFALSNLKAGAKDIL
VATDVIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKED
SAVFYELKQAILESPVSSPPELANHPDAQHKPG
Ligand information
>6qw6 Chain 5 (length=104) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acucugguuucucuucagaucgcauaaaucuuucgcacuaaagauuuccg
uggagaggaacaacucugaguccaauuuuuugaggccuugcuuuggcaag
gcua
<<<<.<<<<<<<<<<<<........<<<<<<<<......>>>>>>>>...
>>>>>>>>>>>....>.>>>>............<<<<<<<<....>>>>>
>>>.
Receptor-Ligand Complex Structure
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PDB6qw6 Mechanism of 5' splice site transfer for human spliceosome activation.
Resolution2.92 Å
Binding residue
(original residue number in PDB)		K271 F272
Binding residue
(residue number reindexed from 1)		K63 F64
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000354 cis assembly of pre-catalytic spliceosome
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0062176 R-loop processing
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0070062 extracellular exosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qw6, PDBe:6qw6, PDBj:6qw6
PDBsum6qw6
PubMed30975767
UniProtQ9BUQ8|DDX23_HUMAN Probable ATP-dependent RNA helicase DDX23 (Gene Name=DDX23)

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