Structure of PDB 6ke6 Chain 5J Binding Site BS01

Receptor Information

>6ke6 Chain 5J (length=144) Species: 559292 (Saccharomyces cerevisiae S288C)

SKFQEIETNLKKLPKLETGFDALANKKKKKNVLPSNDWFTLPKPDDNMRR
EVQRDLLLIKHRAALDPKRHYKKQRWEVPERFAIGTIIEDKMNRKERKST
ILETLMGDEASNKYFKRKYNEIQEKSTSGRKAHYKKMKEMRKKR

Ligand information

>6ke6 Chain 3A (length=175)

gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacu
cuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuu
guacccagugagaaauugccguugcuauggcgcgaugaucacccaugggu
ggguacaaauggcagucugacaagu

..................................................
.......................<<<<<.................<<<<<
<<<<<..<.........<<<<......>>>>........><<<<..>>>>
.>>>>>>>>.>>........>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ke6 3.4 angstrom cryo-EM structure of yeast 90S small subunit preribosome
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): N112 R166 K167
• Binding residue (residue number reindexed from 1): N47 R94 K95

Gene Ontology

Molecular Function

• GO:0003674 molecular_function

Biological Process

• GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006364 rRNA processing
• GO:0006396 RNA processing
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus

External links

• PDB: RCSB:6ke6, PDBe:6ke6, PDBj:6ke6
• PDBsum: 6ke6
• UniProt: Q12035|FCF2_YEAST rRNA-processing protein FCF2 (Gene Name=FCF2)